Bypass agents are the common treatment for haemophilia patients who develop inhibitory antibodies. Laboratory assessment of the efficacy of bypassing agent therapy is a challenge. In the present work we modified the conditions triggering thrombin generation (TG) assay in order to find the most sensitive assay for detection of rFVIIa and its analogue NN1731 in haemophilic plasma. TG was measured...

conclusions although differences between the two products were very close to each other, they reported similar effects on joint bleeds. further clinical studies should be performed by incorporating a standardized measurement in comparative efficacy of apcc and rfviia. results the mean of bleeding reduction in apcc and rfviia were 71.2% with ci 95% (lower limit 86.8% and upper limit 82%) and 72....

The advent of interstitial chemotherapy has significantly increased therapeutic options for patients with malignant glioma. Interstitial chemotherapy can deliver high concentrations of chemotherapeutic agents, directly at the site of the brain tumor while bypassing systemic toxicities. Gliadel, a locally implanted polymer that releases the alkylating agent carmustine, given alone and in combina...