PURPOSE A neural network simulation with realistic cortical architecture has been used to study synchronized bursting as a seizure representation. This model has the property that bursting epochs arise and cease spontaneously, and bursting epochs can be induced by external stimulation. We have used this simulation to study the time-frequency properties of the evolving bursting activity, as well...

The neuromodulatory peptide somatostatin-14 (SRIF) plays an important inhibitory role in epilepsy, but little is known on the signalling mechanisms coupled to this effect of SRIF. We have previously demonstrated that SRIF induces reduction of epileptiform bursting in a model of interictal-like activity in mouse hippocampal slices. In this same model, we investigated whether the cyclooxygenase 2...

An extensive investigation has been made of alleged variables in the bursting test. The studjincluded clamping pressure, nature of clamping surfaces, sizo of bursting orifice, types of diaphragms, effect of manner of installation of diaphragms, effect of air entrapped under diaphragm, speed of operation, effect of viscosity of liquid medium in hydraulic chamber, calibration and performance of p...

The rat is a commonly used model for the study of lower urinary tract function before and after spinal cord injury. We have previously reported that in unanesthetized freely moving rats, although phasic external urethral sphincter (EUS) activity (bursting) is most common during micturition, productive voiding can occur in the absence of bursting, which differs from results seen in anesthetized ...

BACKGROUND The Enseal (Ethicon Endo-Surgery, Blue Ash, Ohio) tissue-sealing device has proven efficacy for ligation of vessels<7 mm in diameter, even with significant supraphysiologic bursting pressures. We aimed to evaluate the safety of Enseal in porcine vessels>7 mm. MATERIALS AND METHODS The lumbar aortas of pigs that were euthanized for unrelated procedures were harvested. A 5- to 6-cm s...

Rhythmic activity within the heartbeat pattern generator of the medicinal leech is based on the alternating bursting of mutually inhibitory pairs of oscillator heart interneurons (half-center oscillators). Bicuculline methiodide has been shown to block mutual inhibition between these interneurons and to cause them to spike tonically while recorded intracellularly (Schmidt and Calabrese, 1992). ...

Synchronized cortical activities in the central nervous systems of mammals are crucial for sensory perception, coordination, and locomotory function. The neuronal mechanisms that generate synchronous synaptic inputs in the neocortex are far from being fully understood. This thesis contributes toward an understanding of the emergence of synchronization in networks of bursting neurons as a highly...