Autoantibodies in the skin and sera of patients with epidermolysis bullosa acquisita bind to a large matrix molecule within the lamina densa region of skin basement membrane. At the site of these immune complexes, the epidermis separates from the dermis, which creates a subepidermal blister just below the lamina densa. The target molecule for the autoantibodies is in close apposition to fibrone...

BACKGROUND Epidermolysis bullosa pruriginosa is a rare clinical subtype of dystrophic epidermolysis bullosa characterized by intense pruritus, secondary scratching-induced lesions, and pronounced scarring. OBSERVATIONS We describe a patient with epidermolysis bullosa pruriginosa who was misdiagnosed as having psychogenic pruritus for several years. Except for nail (toenail) dystrophy, no feat...

A relationship for Pseudostertagia bullosa within the trichostrongyloids has been enigmatic or unresolved. Studies of the synlophe in males and females of P. bullosa revealed a tapering system anterior to the deirids and a pattern of parallel ridges extending to near the caudal extremity in both lateral and median fields. Structurally, the synlophe differs considerably from that seen among the ...

This study aims to determine the relationship between nasal septal deviation, concha bullosa, and chronic rhinosinusitis by using a definitive pathological and simplified model. Fifty-two consecutive sinus computed tomography scans were performed on patients who received endoscopic sinus surgery and whose final diagnosis was paranasal sinus fungus balls. The incidences of nasal septal deviation...

Ichthyosis bullosa of Siemens is a rare autosomal dominant skin disorder whose clinical findings are quite similar to those of epidermolytic hyperkeratosis. The differences between those two diseases include absence of erythroderma and different distributions in the skin in ichthyosis bullosa of Siemens. Recent studies have confirmed that ichthyosis bullosa of Siemens is caused by the mutation ...

Concha bullosa or conchal pneumatization refers to the presence of an air cell within a nasal turbinate. Pneumatization is most commonly seen in the middle turbinate followed by the superior turbinate. Pneumatized inferior turbinate is rare, and most of the papers in the literature appear as case reports. In this study, a 33-year-old female patient complaining from unilateral nasal stuffiness a...

Partial or total pneumatization of the middle turbinate is called concha bullosa. It's one of the most common anatomic variations of the lateral nasal wall. The exact reason of such pneumatization is not known. It can originate from the frontal recess, middle meatus, sinus lateralis or, less frequently, from the posterior ethmoid cells. Concha bullosa remains usually asymptomatic. However, an e...

epidermolysis bullosa (eb) is an inherited disorder, which is characteristically presented as skin blisters developing in response to minor injury. junctional variety of eb is also associated with enamel hypoplasia. amelogenesis imperfecta presents with abnormal formation of the enamel both in deciduous and permanent dentition. this article describes a previously unreported case of amelogenesis...

Dystrophic epidermolysis bullosa is caused by mutations in the COL7A1 gene. The disease characterized clinical heterogeneity. To date, scientific findings allow to evaluate correlations between severity of manifestations and genetic defects underlying development disease. A systematic literature search was performed using PubMed RSCI, keywords including dystrophic bullosa, collagen VII, COL7A1....