Apigenin (4`,5,7-trihydroxyflavone) is a flavonoid of subclass flavones that have antidiabetic therapeutic activity but limitations BCS Class II low solubility 2.16 μg/L. To overcome these limitations, the development nanoemulsion formulation technology, increasing increases dissolution, absorption and bioavailability. It incorporated into buccal film for easy application direct access to syste...

Objective: Buccal drug delivery is the most suited route for local as well systemic of drugs. Cilnidipine an L/N type dihydropyridine 4th generation calcium channel blocker (CCB), which decreases hypertension by blocking N-type to attenuate vascular sympathetic neurotransmission. It has high first-pass metabolism leading low bioavailability. Hence present research work was undertaken formulate ...