1Oral Biology and Anatomy, Ophthalmology and Culver Vision Discovery Institute, College of Dental Medicine and Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA 2Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA 3Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s ...

1Centre for Public Health, Queen’s University Belfast, Belfast BT12 6BA, UK 2Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228 3Health Outcomes Research, Department of Pharmaceutical Systems and Policy, West Virginia University, Morgantown, WV 26505, USA 4State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen Uni...

∗Department of Neurology, York District Hospital, Wigginton Road, York YO3 7HE, UK; †The Roald Dahl EEG Unit, Alder Hey Children’s Hospital, Eaton Road, West Derby, Liverpool L12 2AP, UK; ‡Birmingham University Seizure Clinic, Queen Elizabeth Psychiatric Hospital, Edgbaston, Birmingham B15 2QZ, UK; §The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK; ¶The Su...

[1] The brightness temperature difference (BTD) between two thermal infrared bands is a common index for dust detection. However, the BTD is sensitive to the observed temperature, which hinders its use in automatic dust detection, especially over desert land surfaces. In this paper, a dynamic reference brightness temperature differences (DRBTD) algorithm was developed to detect dust by removing...

BACKGROUND Serum free fatty acids (FFAs) are correlated with pathological status, and change in serum FFA levels may be associated with thyroid diseases. MATERIALS AND METHODS In this study, 664 serum samples from 322 healthy controls, 129 patients with benign thyroid disease (BTD), and 213 patients with thyroid cancer (TC) were collected. Chip-based direct-infusion nanoelectrospray-mass spec...

The US Food and Drug Administration (FDA) has four facilitated regulatory pathways (FRPs): Fast Track (FT), Breakthrough Therapy (BTD), Priority Review (PR), and Accelerated Approval (AA). Only PR specifies an expedited review timeline (6 months). We sought to determine to what extent the combination of two or more FRPs influenced development and approval times. We developed a "metro map" to il...

The block-term decompositions (BTD) represent tensors as a linear combination of low multilinear rank terms and can be explicitly related to the Canonical Polyadic decomposition (CPD). In this paper, we introduce SECSI-BTD framework, which exploits connection between two estimate block-terms rank- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999...

Recordings of neural activity, such as EEG, are an inherent mixture of different ongoing brain processes as well as artefacts and are typically characterised by low signal-to-noise ratio. Moreover, EEG datasets are often inherently multidimensional, comprising information in time, along different channels, subjects, trials, etc. Additional information may be conveyed by expanding the signal int...

A bi-thiadiazole derivative, 5,5'-bis(4- tetradecyloxyphenyl)-2,2'-bi-1,3,4-thiadiazole (BTD-14), was revealed to exhibit an extremely stable thermotropic SmC phase and very interesting aggregation behavior in solutions. H- and J-aggregates could be formed simultaneously in chloroform solutions of BTD-14 with moderate concentration (10(-4) M), and the population of J-aggregates enlarges during ...

We report three symptomatic children with profound biotinidase deficiency from Sri Lanka. All three children presented with typical clinical features of the disorder. The first is homozygous for a missense mutation in the BTD gene (c.98_104 del7insTCC; p.Cys33PhefsX36) that is commonly seen in the western countries, the second is homozygous for a novel missense mutation (p.Ala439Asp), and the t...