BACKGROUND Bronchial asthma is a chronic respiratory disorder characterized by airway inflammation, airway hyperresponsiveness, and periodic reversible airway obstruction. Subtype 2 helperT cell (T(H)2) cytokines play an important role in the development of allergic airway inflammation in patients with bronchial asthma. OBJECTIVE To investigate whether the single-nucleotide polymorphisms (SNP...

Asthma with bronchial hypersecretion is a type of asthma that is poorly studied. Its pathogenesis is not well understood, but is probably related to innate impaired immunity, particularly with toll-like receptors (TLRs) and secretory mucins (MUC). OBJECTIVES 1) Define the clinical and inflammatory phenotype of asthma with bronchial hypersecretion of mucus. 2) Compare the type of mucin present...

The prevalence of asthma in children is increasing worldwide. Although the features of asthma are well documented, defining asthma remains a problem. The clinical definition of asthma does not take into account the concept of airway inflammation. A broader definition that incorporates the inflammatory process, reversibility of airway obstruction, and airway responsiveness needs to be more widel...

Beta-2-agonists continue to find a dominant role in all the current guidelines on the management of chronic persistent bronchial asthma. However, the safety of the drugs remains doubtful. Thus, there is a case for review of the "Step up-Step down" approach in the management of chronic persistent bronchial asthma. Based on the currently available experimental and clinical data on bronchial asthm...

Studies have shown that eosinophils are closely related to pathogenesis of bronchial asthma. Eosinophils release eosinophil cationic protein (ECP), which plays an important role in infection and allergic reactions. Serum ECP mRNA expression in children with bronchial asthma has not been adequately investigated. We analyzed serum ECP mRNA expression in 63 children with bronchial asthma and 21 he...

Finger tip patterns of sixty patients of Bronchial Asthma were compared with that of 50 control cases. Higher frequency of whorls was observed in first digit of both generations of bronchial asthma patients in comparison to controls. In all digits the frequency of arches was reduced in both generations of bronchial asthma patients as compared to controls. These findings proved highly significan...

Bronchial Asthma is a major non-communicable disease affecting both children and adults, nearly 262 million people in India suffer from asthma (WHO). It chronic disorder that affects the airways characterized by bronchial hyper-reactivity reversible airway obstruction. could be correlated as Tamak shwasa Ayurveda considered Pranvaha srotho vikara. The Pathya Aahar Vihara, having Vata Kapha alle...

BACKGROUND There are studies indicating that bronchial asthma is often underdiagnosed, while only a little research has been conducted as concerns overdiagnosing asthma. OBJECTIVE We aimed to estimate the number of patients who have been given the wrong diagnosis of asthma. METHODS All patients aged above 18 years who had visited two GPs during 1994 or 1995, with the diagnosis of bronchial ...

To clarify the interrelation between interleukin-2 (IL-2) and soluble IL-2R receptor (sIL-2R), as products of T-cell activation in the bronchial tree of patients with bronchial asthma, we measured the concentration of IL-2, sIL-2R, and the cellular composition in bronchoalveolar lavage (BAL) fluid. We also measured physiologic parameters, including provocation concentration of histamine require...

BACKGROUND Increased proliferation of bronchial smooth-muscle cells may lead to increased muscle mass in the airways of patients with asthma. The antiproliferative effect of glucocorticoids in bronchial smooth-muscle cells in subjects without asthma is mediated by a complex of the glucocorticoid receptor and the CCAAT/enhancer binding protein alpha (C/EBPalpha). We examined the signaling pathwa...