Pseudomonas aeruginosa PAO1 is repelled by trichloroethylene (TCE), and the methyl-accepting chemotaxis proteins PctA, PctB, and PctC serve as the major chemoreceptors for negative chemotaxis to TCE. In this study, we found that the pctABC triple mutant of P. aeruginosa PAO1 was attracted by TCE. Chemotaxis assays of a set of mutants containing deletions in 26 potential mcp genes revealed that ...

The objective of this study was to identify the main sources of variation in pesticide losses at field and catchment scales using the dual permeability model MACRO. Stochastic simulations of the leaching of the herbicide MCPA (4-chloro-2-methylphenoxyacetic acid) were compared with seven years of measured concentrations in a stream draining a small agricultural catchment and one year of measure...

One of the phenoxy herbicides, 2-methyl-4-chlorophenoxyacetic acid (MCPA) was soaked with pellet dissolved by corn oil and given to ICR male mice for 18 months at levels of 40, 200, 1,000 and 5,000 ppm (about 3.9, 19.0, 95.6 and 566.4 mg/kg/day, respectively). The animals were then placed on a control diet for 12 months. Treatment with 5,000 ppm of MCPA resulted in a significantly decreased sur...

this study was conducted in the research field of iranian research institute of plant protection in karaj as strip split plots with three replications. the first factor: tillage and no-tillage, and the second factor: herbicide: glyphosate 6 l/ha, 2,4-d + mcpa 2l/ha, glyphosate + 2,4-d + mcpa (6 + 2 l/ha), glyphosate 3 l/ha, 2,4-d + mcpa 1 l/ha, glyphosate + 2,4-d + mcpa (3 + 1 l/ha), and contro...

Multiple-herbicide-resistant (MHR) Canada fleabane [Conyza canadensis (L.) Cronq.] control has become a major concern for corn producers in Ontario. Postemergence (POST) herbicides are critical the of emerged MHR corn. A study that consisted five field experiments was conducted southwestern Ontario fields with confirmed to evaluate various herbicide mixtures applied POST Glyphosate + 2,4-D amin...

A population pharmacokinetic model is proposed for estimation of the brain distribution clearance of synthetic A1 receptor agonists in vivo. Rats with permanent venous and arterial cannulas in combination with a microdialysis probe in the striatum received intravenous infusions of 8-methylamino-N6-cyclopentyladenosine (MCPA) and 2'-deoxyribose-N6-cyclopentyladenosine (2'-dCPA) (10 mg kg(-1)). T...

BACKGROUND Increased intake of probiotic dietary fibre reduces colonic cancer risk. Modified citrus pectin (MCP) requires optimal bioactivity to inhibit galectin-3 (GAL-3) and vascular endothelial growth factor (VEGF). This study evaluated the preventative effect of modified pectin alginate (MCPA) probiotic microbeads on azoxymethane (AOM)-induced colonic carcinogenesis in Balb/c mice. MATERI...

The biological efficacy of herbicides MCPA+tribenuron-methyl (code name: MT-565 SG) and diflufenican+chlorotoluron (Legato Pro 425 SC) was estimated in eighteen field experiments on winter cereals Poland Germany to control broadleaf weeds. Postemergence application tribenuron-methyl combination with MCPA, applied at the 3-leaf stage 3 tillers detectable autumn cereals, resulted majority weed sp...

Future cancer immunotherapies will combine multiple treatments to improve immune responses to cancer through synergistic, multi-modal mechanisms. In a Phase I clinical trial, we found that the immune response to a peptide vaccine targeting survivin, DPX-Survivac, by ovarian cancer patients can be improved by combination therapy with metronomic cyclophosphamide (mCPA). Pre-clinical studies in mi...