We studied several relevant biological aspects of breath-alcohol, analysis in 55 healthy men and women, after alcohol ingestion and during breathalcohol analysis with a typical 4th-generation instrument. We measured breath volumes, delivery pressures, and end-expiratory temperatures, with the following findings: End-expiratory temperature, 32.4135.69 #{176}C (mean, 34.53 #{176}C); forced vital ...

Breath analysis is becoming increasingly established as a means of assessing metabolic, biochemical and physiological function in health and disease. The methods available for these analyses exploit a variety of complex physicochemical principles, but are becoming more easily utilised in the clinical setting. Whilst some of the factors accounting for the biological variation in breath metabolit...

BACKGROUND Healthcare associated infections, including ventilator associated pneumonia, are difficult to diagnose and treat, and are associated with significant morbidity, mortality and cost. We aimed to demonstrate proof of concept that breath volatile profiles were associated with the presence of clinically relevant pathogens in the lower respiratory tract. METHODS Patients with sterile bra...

The goal of the project is to carry out fundamental research focused on the development semiconductor, resistive gas sensors based on metal oxides with dopants for selective trace detection of the diabetes biomarkers present in the human breath. The exhaled breath is a composition of gases: humidity, carbon dioxide, oxide, nitrogen and volatile organic compounds (VOCs). The majority breath samp...

Ancient Greek physicians already knew that the smell of human breath could provide a clue to the pathology. Nowadays, volatile breath biomarkers are known to be released in a broad range of diseases. However, their identification, isolation, and quantification as indicative of relevant alterations in clinical status have required the development of new techniques and analytical methods. Breath ...

Online breath analysis is an attractive approach to track exhaled compounds without sample preparation. Current commercially available real-time breath analysis platforms require the purchase of a full mass spectrometer. Here we present an ion source compatible with virtually any preexisting atmospheric pressure ionization mass spectrometer that allows real-time analysis of breath. We illustrat...

The use of breath tests to assess the extent of alcohol use has become a standard procedure in the enforcement of impaired driving laws in many countries around the world. In Canada, if a police officer has a reasonable suspicion that a driver has consumed alcohol, he or she can demand the driver provide a sample of breath for analysis using an approved screening device (ASD). “Random” or “mand...