We previously reported that brain derived neurotrophic factor (BDNF), a pronociceptive neurotransmitter, induces synaptic facilitation of EPSC in lamina II neurons of neonatal rats up to P14 in an NMDA-receptor dependent manner (Garraway et al. 2003). Here we used the patch-clamp technique to study synaptic and NMDA-evoked responses in transverse spinal slices in the lumbar enlargement as well ...

A 61-year-old male presented with a rare case of glioblastoma mimicking a cerebral contusion subsequent to collapsing. The patient had been medicated for hypertension for seven years and diabetes for eight years prior to hospitalization. Brain computed tomography (CT) revealed a cerebral contusion and intracerebral hemorrhage (ICH) in the left temporal region. The patient was initially administ...

Traumatic brain injury is one of the leading causes for cognitive-linguistic impairments in individuals. Considering cerebral lateralization, type communication does depend on hemisphere that damaged. The current study reports about a 26-year-old female who has underwent right fronto-temporo-parietal (FTP) craniotomy and evacuation acute subdural hematoma, followed by left FTP decompressive con...

introduction: traumatic brain injuries (tbi) are one of the most important causes of death in patients under the age of 25 years and is responsible for one third of total deaths caused by trauma. therefore, knowing its epidemiologic pattern in different populations seems vital. therefore, this study aims to examine the epidemiologic pattern of tbi in emergency department. methods: in this cross...

Nowadays, head injuries are becoming more frequent in children. The most common cause of head injuries in children is fall, and, in more severe injuries, traffic accident trauma. In traumatic brain injuries in infants and small children, the most common symptoms are paleness, somnolence and vomiting, the so called "pediatric contusion syndrome". After the first year of age, light head trauma oc...

The mechanisms accounting for the development of tissue damage following traumatic brain injury (TBI) have been studied for several decades. A variety of mediators, such as vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9), which play a crucial role in edema formation after TBI, have been identified. We experienced a case of brain edema that progressed continuousl...

Relationships Between Cerebral Perfusion Pressure and Regional Cerebral Blood Flow in Patients With Severe Neurological Disorders • Three patients, one with a recurrent brain tumor, one with a severe brain contusion, and one with a brain abscess, are described who had continuous monitoring of the intracranial pressure with epidural and/or ventricular pressure transducers, continuous monitoring ...

We previously reported that brain-derived neurotrophic factor (BDNF), a pronociceptive neurotransmitter, induces synaptic facilitation of excitatory postsynaptic current (EPSC) in lamina II neurons of neonatal rats up to P14 in a N-methyl-d-aspartate (NMDA) receptor-dependent manner. Here we used the patch-clamp technique to study synaptic and NMDA-evoked responses in transverse spinal slices i...

Danger-associated molecular patterns are released by damaged cells and trigger neuroinflammation through activation of non-specific pattern recognition receptors, e.g., toll-like receptors (TLRs). Since the role of TLR2 and 4 after traumatic brain injury (TBI) is still unclear, we examined the outcome and the expression of pro-inflammatory mediators after experimental TBI in Tlr2/4-/- and wild-...