Maternal alcohol consumption during pregnancy can cause serious birth defects, of which fetal alcohol syndrome (FAS) is the most devastating. Recognizable by characteristic craniofacial abnormalities and growth deficiency, this condition includes severe alcohol-induced damage to the developing brain. FAS children experience deficits in intellectual functioning; difficulties in learning, memory,...

Deep unsupervised representation learning has recently led to new approaches in the field of Unsupervised Anomaly Detection (UAD) brain MRI. The main principle behind these works is learn a model normal anatomy by compress and recover healthy data. This allows spot abnormal structures from erroneous recoveries compressed, potentially anomalous samples. concept great interest medical image analy...

We introduce a neural network framework, utilizing adversarial learning to partition an image into two cuts, with one cut falling reference distribution provided by the user. This concept tackles task of unsupervised anomaly segmentation, which has attracted increasing attention in recent years due their broad applications tasks unlabelled data. Adversarial-based Selective Cutting (ASC-Net) bri...

iii Acknowledgments iv List of Figures ix

Holoprosencephaly (HPE) is a rare anomaly of the brain consisting of an absent or incomplete separation of the forebrain in early gestation. We present 2 variants of HPE, diagnosed by ultrasound, which combined with the clinical features led to HPE subtypes differentiation.

Holoprosencephaly is a rare congenital brain malformation resulting from failure of diverticulation and cleavage of primitive prosencephalon which occurs at 4th 8th week of gestation and is usually associated with multiple midline facial anomalies. Herein we report an antenatal case of such patient. Patient was evaluated and because of the magnitude of the problem induction was done which led t...