Several aminoacyl-tRNA synthetases have been reported to be overexpressed for charging essential aminoacyl-tRNAs in many cancer types. In this study, we aimed to explore the potential role of leucyl-tRNA synthetase (LARS) as an anticancer target. MTT assay was performed to screen inhibitors to human LARS (hsLARS) from compounds AN2690 and its derivatives, compounds 1-6, in U2OS and SKOV3 cells....

On Tuesday 28 June 2011, Lars Haaheim tragically died whilst on a fishing trip in a fjord near his summer home in Sveio, Norway. Lars was an internationally renowned influenza scientist and a founder member of the International Society for Influenza and Other Respiratory Viruses (isirv). From his formative academic years at the University of Bergen, Lars was an influenza enthusiast. He speciali...

The American Cancer Society estimated that 39,610 new cases of rectal cancer were diagnosed in the United States in 2015. Surgery is the primary treatment for rectal cancer, with the majority of patients undergoing sphincter-preserving surgery with low anterior resection. Although low anterior resection can prevent patients from having a permanent colostomy, bowel dysfunction may occur in 60% t...

As ever-larger knowledge bases (KBs) are being built, knowledge sharing becomes an aspect of paramount importance in Knowledge Base Management Systems (KBMSs). In this paper, we propose a way of controlling knowledge sharing by means of the LARS (Locks using Abstraction Relationships’ Semantics) approach for concurrency control in KBs. LARS synchronizes transactions through many different granu...

Professor Lars Mehlum er tildelt Schizofrenidagenes ærespris for sin forskning og sitt arbeid mot stigma.