RATIONALE There is a need to expand knowledge on cardio-pulmonary pathophysiology of bronchiolitis obliterans syndrome (BOS) following lung transplantation (LTx). OBJECTIVES The purpose of this study was to assess MRI-derived biventricular cardiac mass and function parameters as well as flow hemodynamics in patients with and without BOS after LTx. METHODS Using 1.5T cardiac MRI, measurement...

Bronchiolitis obliterans syndrome (BOS) is the most important cause of late mortality following lung transplantation, resulting in major morbidity and a huge burden on healthcare resources. Treatment options are limited, resulting in a mere stabilisation of the lung function decline. Recent introduction of the macrolide antibiotic azithromycin raised new hope after demonstrating lung function i...

Auditory neurons of the anterior forebrain (AF) in adult zebra finches are highly selective for the bird's own song (BOS): they respond more to BOS than to songs of other zebra finches (conspecifics) and to BOS played in reverse. In contrast, juvenile AF neurons are not selective at 30 d of age, responding equally well to all song stimuli. Both BOS and tutor song experience are required by juve...

BACKGROUND Long-term lung transplant success is limited by bronchiolitis obliterans syndrome (BOS), a form of chronic allograft rejection that manifests in the majority of patients by five years post-transplant. Frequent monitoring of pulmonary function measurements through the use of daily home spirometry may have the capability to detect the onset of BOS sooner than standard pulmonary functio...

BACKGROUND Blood oxygen saturation (BOS) is decreased in a low-compliant, overactive obstructed bladder. The objective of this study is to determine the effect of Sildenafil (SC) on bladder function and BOS) in an in vivo animal model of bladder outlet obstruction. METHODS Thirty-two guinea pigs; sham operated (n = 8), sham operated + SC (n = 8), urethrally obstructed (n = 8) and urethrally o...

INTRODUCTION A recent pilot study noted clinical benefit of macrolide therapy in the management of six lung transplant recipients with bronchiolitis obliterans syndrome (BOS), a condition previously regarded as irreversible. OBJECTIVE To examine the effect of low-dose macrolides on lung function in lung allograft recipients with established BOS and to assess whether this benefit is sustained....

CD59 is a complement regulatory protein that inhibits membrane attack complex formation. A soluble form of CD59 (sCD59) is present in various body fluids and is associated with cellular damage after acute myocardial infarction. Lung transplantation (LTx) is the final treatment for end-stage lung diseases, however overall survival is hampered by chronic lung allograft dysfunction development, wh...

PURPOSE The development of bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (HSCT) deteriorates patients' quality of life. This study aimed to analyze the prevalence, clinical features, risk factors and prognostic factors of BOS. MATERIALS AND METHODS This retrospective study included patients who underwent allogeneic HSCT from January 2002 to D...

Azithromycin reduces airway inflammation and improves forced expiratory volume in 1 s (FEV₁) in chronic rejection or bronchiolitis obliterans syndrome (BOS) after lung transplantation (LTx). Azithromycin prophylaxis might prevent BOS. A double-blind randomised controlled trial of azithromycin (n = 40) or placebo (n = 43), initiated at discharge and administered three times a week for 2 yrs, was...

0 0 Bet v 4 0 0 0 0 0 0.52 0 0 0 0 0 Bla g 1 0 0 0 0 0 0 0 0 0 0 0 Bla g 2 8.99 6.38 3.35 1.93 1.81 0 0 0 0 0 0 Bla g 5 20.09 0 0 0 0 0.23 0 0 0 0 0 Bla g 7 0 0 0 0 3.14 0 0 0 0 0 0 Blo t 5 0 0 0 0 0 0 0 0 0 0 0 Bos d 4 0 0 0 0 0 0 0 0 0 0 0 V Bos d 4 0 0 0 0 0 0 0 0 0 0 0 Bos d 5 3.71 0 0 0 0.92 0 0 0 0 0 0 V Bos d 5 37.66 21.94 9.83 3.71 5.35 0 0 0 0 0 0 Bos d Lactoferrin 32.92 14.67 7.56 4.1...