Exposure to blast overpressure (BOP) activates a cascade of pathological processes including changes in intracranial pressure (ICP) and blood-brain barrier (BBB) permeability resulting in traumatic brain injury (TBI). In this study the effect of single and multiple exposures at two intensities of BOP on changes in ICP and BBB permeability in Sprague-Dawley rats was evaluated. Animals were expos...

N-Nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) proved to be a potent carcinogen in Syrian golden hamsters. The compound is an in vivo metabolite of N-nitrosobis(2-hydroxypropyl)amine, N-nitrosobis(2-oxopropyl)amine (BOP), and N-nitroso-2,6-dimethylmorpholine and a postulated proximate pancreatic carcinogen in hamsters. As with BOP, HPOP induced a higher incidence of pancreatic ductular ade...

The structure of the complex between carboxypeptidase A alpha (EC 3.4.17.1) and the ketonic substrate analogue 5-benzamido-2-benzyl-4-oxopentanoic acid (BOP) has been determined by x-ray crystallographic methods to a resolution of 1.7 A (final R = 0.191). Interestingly, BOP was observed to bind to the active site of carboxypeptidase A alpha as the covalent hydrate adduct. Because BOP is probabl...

Background According to the Spanish Society of Cardiology, 700,000 patients receive oral anticoagulants, and in these cases bleeding on probing (BOP) could be altered. However, no studies have analyzed the periodontal status of these patients and the effects anticoagulants may have upon BOP. A study was made of the possible relationship between plaque index, probing depth, INR (International No...

The mutagenic activity of A/-nitrosobis(2-oxopropyl)amine (BOP), A/-nitroso(2-hydroxypropyl) (2-oxopropyl)amine (HPOP), N-nitrosobis(2-hydroxypropyl)amine (BHP), /V-nitrosomethyl-2-oxopropylamine (MOP), and W-nitrosomethyl-2-hydroxypropylamine (MHP) was examined in the Ames liquid incubation assay, using hamster liver homogenate for meta bolic activation, and in the hamster liver cell-mediated ...

We have determined the sequence of the inverted repeats and duplicated target DNA of the halobacterial insertion elements ISH2 (520 bp), ISH23 (900 bp) and ISH24 (3000 bp) associated with bacterio-opsin (bop) mutants. ISH2 has a perfect 19 bp inverted repeat (3,5), while both ISH23 and ISH24 have imperfect inverted repeats of 29 bp and 14 bp respectively. ISH23 was shown to be highly homologous...

This study focuses on the supplemented strategies of microfinance institutions (MFIs), in which the MFI offers nonfinancial services, such as entrepreneurship related knowledge, in addition to financial services to impoverished borrowers at the bottom of the pyramid (BoP). We examine two contextual factors–foreign direct investment (FDI) and loan defaults–to better understand the relationship b...

China has a largest population in the world (1.3Billion) and 0.9 Billion is rural population. Most of rural people earn less than US$3/day, and they are called 'Base of the economic pyramid (BoP)'. Compared with high level market, BoP is a new market, which means a low individual profit, but a large population. This paper discusses the healthcare issues in rural China (BoP) and study their heal...

The radiolabeled thromboxane As/prostaglandin HZ (TXAZ/PGHZ) agonist “‘1-BOP bound to the TXAs/ PGHZ receptor on human platelet membranes. Scatchard analysis showed that pretreatment of platelet membranes with the reducing agent dithiothreitol (DTT) (10 mM) for 10 min decreased maximal “‘IBOP binding (B,,,*J from 1.51 2 0.11 pmol/mg to 0.61 2 0.05 pmol/mg (p = 0.001) and increased the affinity ...

A model-based approach was used to develop performance measures from inmate misconduct data to compare public and private prisons. The performance measures indicated the impact of different prisons upon raising or lowering the probability of inmate misconduct. Data for all misconduct and two categories of misconduct, violent and drug, were generated for the 36 month period between January of 19...