In this issue of Cell, McDonald et al. show that giant multinucleated, bone-resorbing osteoclasts dissolve into smaller cells, termed “osteopmorhs,” which re-form at distal bone sites (McDonald al., 2021McDonald M.M. Khoo W.H. Ng P.Y. Xiao Y. Zamerli J. Thatcher P. Kyaw W. Pathmanandavel K. Grootveld A.K. Moran I. al.Osteoclasts recycle via osteomorphs during RANKL-stimulated resorption.Cell. 2...

Bone mass is maintained constant in vertebrates through bone remodeling (BR). BR is characterized by osteoclastic resorption of preexisting bone followed by de novo bone formation by osteoblasts. This sequence of events and the fact that bone mass remains constant in physiological situation lead to the assumption that resorption and formation are regulated by each other during BR. Recent eviden...

Cellular mechanisms accounting for the osteolysis of rheumatoid erosions are poorly understood. Cells were isolated and characterised from the synovium of 16 patients with rheumatoid arthritis (RA) and four patients with osteoarthritis and their ability to resorb bone was assessed using a scanning electron microscope bone resorption assay. Macrophages were the major cell type isolated from the ...

In this work, a bone damage resorption finite element model based on the disruption of the inhibitory signal transmitted between osteocytes cells in bone due to damage accumulation is developed and discussed. A strain-based stimulus function coupled to a damage-dependent spatial function is proposed to represent the connection between two osteocytes embedded in the bone tissue. The signal is tr...

Introduction. In children and growing adolescents, ankylotic resorption (i.e., progressive replacement resorption) of a permanent tooth is serious complication. An ankylosed root continuously resorbed replaced with bone; normal growth alveolar bone disturbed infraposition the dental crown progresses. This article aims to present decoronation as very good treatment option for incisors diagnosed ...

background mandibular continuity defects occur after tumor resection, maxillofacial injury, or osteomyelitis. despite the current availability of a plethora of treatment modalities, bone substitutes, and various clinical adjuncts, an exact reconstructive recapitulation of large bony defects continues to be beyond reach. in this clinical pilot study, we report a novel method for reconstruction o...

Bone is a preferred site for breast cancer metastasis and leads to pathologic bone loss due to increased osteoclast-induced bone resorption. The homing of tumor cells to the bone depends on the support of the bone microenvironment in which the tumor cells prime the premetastatic niche. The colonization and growth of tumor cells then depend on adaptations in the invading tumor cells to take adva...

PURPOSE This prospective study aimed to examine postoperative dimensional changes in the buccal bone and mucosa around single-stage implants placed in the posterior region. MATERIALS AND METHODS The dimensions of peri-implant tissue around screw-type implants placed in the posterior region were examined at surgery (baseline) and 6 months and 1 year after surgery. The lateral contour of the bu...

Bone mass accrual is a major determinant of skeletal mass, governed by bone remodeling, which consists of bone resorption by osteoclasts and bone formation by osteoblasts. Bone mass accrual is inhibited by sympathetic signaling centrally regulated through activation of receptors for serotonin, leptin, and ACh. However, skeletal activity of the parasympathetic nervous system (PSNS) has not been ...

Bone that was virtually depleted of the vitamin K-dependent protein, osteocalcin, and 93% reduced in the concentration of its characteristic amino acid, gamma-carboxyglutamic acid, was obtained from rats treated with warfarin for 6 wk. Osteocalcin-deficient bone particles were resistant to resorption when implanted subcutaneously in normal rats. The relative resorption was 60% of control bone, ...