نتایج جستجو برای: bone morphogenetic protein 4
تعداد نتایج: 2612758 فیلتر نتایج به سال:
Pulmonary arterial hypertension is characterized by pulmonary vascular remodeling, cellular proliferation, and poor long-term outcomes. Dysfunctional bone morphogenetic protein pathway signaling associated with both hereditary idiopathic subtypes. Sotatercept, a novel fusion protein, binds activins growth differentiation factors in the attempt to restore balance between growth-promoting growth-...
Bone morphogenetic proteins (BMPs) perform diverse functions in vertebrate development. Here we demonstrate that the heterodimeric BMP-4/7 protein directly induces ventral mesoderm and blood in Xenopus animal caps, and BMP-2/7 heterodimers may function similarly. We also provide indirect evidence that BMP heterodimers function in embryos, using assays with dominant-negative BMP ligands. Homodim...
Bone morphogenetic proteins (BMPs) are known as ectopic bone inducers. The FDA approved BMPs (BMP2 and BMP7) for clinical use. However, direct effects of BMPs on endogenous bone metabolism are not yet well known. We recently reported that loss of BMPRIA (ALK3), a potent receptor for BMP2 and BMP4, in osteoblasts unexpectedly increased endogenous bone mass during embryonic and adult stages (ref ...
Glioblastoma cells with stem-like properties control brain tumour growth and recurrence. Here, we show that endogenous neural precursor cells perform an anti-tumour response by specifically targeting stem-like brain tumour cells. In vitro, neural precursor cells predominantly express bone morphogenetic protein-7; bone morphogenetic protein-7 is constitutively released from neurospheres and indu...
Visualizing Smad1/4 signaling response to bone morphogenetic Protein-4 activation by FRET biosensors
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید