Abstract The regulation and maintenance of bone metabolic homeostasis are crucial for animal skeletal health. It has been established that structural alterations in the gut microbiota ecological dysbiosis closely associated with homeostasis. its metabolites, especially short-chain fatty acids (SCFAs), affect almost all organs, including bone. In this process, SCFAs positively healing by acting ...

background: in this study, we determined the serum levels of il-17a and il-10 in context with 1, 2 dihydroxy vitamin d3, parathormone and ca2+/pi ions to investigate their pathological or protective roles respectively in bone metabolism. methods: the bone mineral density (bmd) was determined for 1203 participants using energy x-ray absorptiometry. subjects with a history of diseases and using b...

Maintenance of mitochondrial homeostasis is crucial for ensuring healthy mitochondria and normal cellular function. This process primarily responsible regulating processes that include OXPHOS, which generates ATP, as well oxidative stress, apoptosis, calcium homeostasis, mitophagy. Bone mesenchymal stem cells express factors aid in bone formation vascular growth. Positive regulation hematopoiet...

Bone-marrow mesenchymal stem cell (BM-MSC) proliferation and lineage commitment are under the coordinated control of metabolism epigenetics; MSC niche contains low oxygen, which is an important determinant cellular metabolic state. In turn, drives fate decisions via alterations chromatin landscape. Due to fundamental role BM-MSCs in development adipose tissue, bones cartilage, age-associated ch...

Introduction: Experimental evidence suggests positive effects of physical activity on skeletal mass. Biochemical markers determine the response rate of bone metabolism to physical activity. Therefore, the aim of this study was to investigate the effect of Pilates exercise training on serum osteocalcin and parathormone levels in inactive and overweight women. Methods: 28 healthy overweight wome...

The publication focuses on the presentation of role vitamin D3 in human body. content contains important information influence course Covid-19 disease caused by Sars-Cov-19 virus. Cholecalciferol has been studied for years. Its basic functions include regulation bone mineral metabolism and calcium-phosphorus metabolism. In addition, characterizes synthesis presents Additionally, currently condu...

Our study evaluated the effects of one year-treatment with Denosumab (DB) on bone mineral density (BMD), FRAX SCORE, metabolism (MM) parameters and safety in 32-kidney transplanted patients (KTxps).

The available data indicate that HIV-infected children and adolescents have reduced bone mass compared to healthy peers. The increased survival due to the control of HIV infection by potent antiretroviral treatment, exposes patients to the achievement of a reduced peak bone mass and to an increased fracture risk during adult life. Reduced bone mass in HIV-infected children is the result of alte...