background: spinal cord has a limited capacity to repair therefore, medical interventions are necessary for treatment of injuries. transplantation of schwann cells has shown a great promising result for spinal cord injury (sci). however, harvesting schwann cell has been limited due to donor morbidity and limited expansion capacity. furthermore, accessible sources such as bone marrow stem cells ...

objective(s): although many researchers have confirmed induction of germ cells from bone marrow mesenchymal stem cells (bmmscs), there are no reports that confirm spontaneous differentiation of germ cells from bmmscs. in this study, we have evaluated the effect of adult sertoli cell condition medium (sccm) as a mutative factor in the induction of germ cells from bmmscs. materials and methods: b...

the sequestration of rat leukocytes and bone marrow cells by the lung vasculature was studied using an isolated perfused rat lung preparation. the passage of latex particles of 7.6 µm in diameter and non-hematopoietic cells through the lung blood vessels was also studied. leukocytes and bone marrow cells were reversibly sequestered from circulation, whereas, latex particles and non-hematopoieti...

Background: Recent clinical studies of treating traumatic brain injury (TBI) with autologous adult stem cells led us to compare effect of intravenous injection of bone marrow mesenchymal stem cells (BMSC) and bone marrow hematopoietic stem cell mobilization, induced by granulocyte colony stimulating factor (G-CSF), in rats with a cortical compact device. Methods: Forty adult male Wistar rats w...

background and objectives: bone marrow necrosis (bmn) is a rare and ominous complication of wide variety of diseases including hematologic malignancy. this study was performed to identify frequency and the underlying associated diseases of marrow necrosis. materials and methods: in this descriptive study, totally 850 bone marrow trephine biopsies related to living patients at the pathology depa...

In the bone marrow, there are certain populations of stem cell sources with the capacity to differentiate into several different types of cells. Ideally, cell transplants would be readily obtainable, easy to expand and bank, and capable of surviving for sufficient periods of time. Bone marrow mesenchymal stem cells (BM-MSCs) possess all of these characteristics. One of the most important benefi...

Lithium content does not underlie the bioactive effects of LAPONITE® on human bone marrow stromal cell osteogenic activity.

background: bone marrow has recently been recognized as a novel source of stem cells for the treatment of wide range of diseases. a number of studies on murine bone marrow have shown a homogenous population of rare stage-specific embryonic antigen 1 (ssea-1) positive cells that express markers of pluripotent stem cells. this study focuses on ssea-1 positive cells isolated from murine bone marro...

Introduction: The use of cord stem cells, as a cell source for bone marrow reconstruction in patient under hematopoietic stem cell transplantation is enhancing. The amount of CD34+cells collected from cord blood compared to peripheral blood and bone marrow are less, but their collectionprocesure is easier. Delay in freezing has negative effect on cells surveillance and reduce their ability in ...