Early bone development may have a significant impact upon bone health in adulthood. Bone mineral density (BMD) and bone mass are important determinants of adult bone strength. However, several studies have shown that BMD and bone mass decrease after birth. If early development is important for strength, why does this reduction occur? To investigate this, more data characterizing gestational, in...

Purpose: To investigate the roles of osteomodulin (OMD), a small proteoglycan known for controlling collagen fibrils organization in bone, development osteoarthritis (OA) associated with subchondral bone sclerosis.