The first gene profiling study of cancer-specific CD8+ T-cells demonstrates that lymphocyte dysfunction in cancer tissue is due to multiple molecular alterations,(1) similar as in "exhausted" T-cells in chronic infection.(2) The data suggest novel drug targets, and show that T-cell exhaustion is reversible and limited to anatomical sites of disease.

The research in this paper quantifies the solar erythemal UV exposures to the skin through a common summer garment during outdoor activities. The erythemal exposures under the garment for the wet white garment exceeded a MED (minimum erythemal dose) at some anatomical sites in summer for a two-hour period. An erythemal exposure of 1.7 MED, in excess of the occupational limit for UV exposure, wa...

Hyperhidrosis, characterized by excess sweat production, affects children and adults. Primary focal hyperhidrosis affects any anatomic region with sweat appendages present. Primary hyperhidrosis has traditionally been considered a problem for adults, but approximately 1.6% of adolescents and 0.6% of prepubertal children are affected. Psychological and social development and well-being are often...

The ciliary bodies from four rhesus monkey and six human eyes were subdivided into eight adjacent zones. The morphology of the ciliary epithelium and bordering stroma at the crests of the processes was examined electron microscopically in each region. In two of the monkey eyes (3 months and 18 years old) and in two of the human eyes (18 years and 55 years old) profiles of mitochondria, rough en...

This study investigated the discomfort caused by car driving. Discomfort estimates were achieved by self-administered questionnaire, measured by different testing methods, and through the goniometry of principal angles. Data from a total of 200 non-professional drivers who fulfilled the questionnaire was analysed. 118 subjects were analysed by goniometry and 30 drivers were assessed using the O...

Narrow-Band Ultraviolet B (NB-UVB) in combination with topical therapy is a widely used treatment for non-segmental vitiligo (NSV). The location of the lesions influence on potential repigmentation response after therapy. To date however, these differences therapeutic between specific anatomical areas body have not been fully characterized. This study aimed to evaluate clinical NB-UVB 19 differ...

INTRODUCTION The development of tissue expansion technique as an important routine procedure in plastic and reconstructive surgery in the past two decades reflects the tendency of getting quality skin that would replace the defect. The aim of this study was to present our experience in the application of tissue expanders in the limbs, and to compare the complications of this procedure in limb a...