The recent WHO classification of skin tumors has underscored the importance acknowledging intermediate grade melanocytic proliferations. A multistep acquisition oncogenic events drives progressive transformation nevi into melanomas. various pathways described are modulated by initial drivers that define common, blue, and Spitz groups. Intermediate lesions most often result a clonal evolution wi...

IMPORTANCE Apart from the atypical mole phenotype, development of new melanocytic nevi in older individuals is uncommon and considered worrisome for melanoma. We performed a retrospective case series in a Veterans Affairs population from 1991 to 2013 to characterize blue nevi (BN) by patient age at biopsy, location, self-reported duration, and relation to prior or subsequent development of cuta...

Dermoscopy plays an important role in the diagnosis of pigmented lesions, particularly in the differential diagnosis of early-stage melanoma. Dermoscopy systems that aim to enable automatic "unmanned-without physician" diagnosis are becoming increasingly common. We aimed to investigate the reliability and weaknesses of diagnosis programs. Furthermore, we attempted to determine whether such prog...

BACKGROUND Congenital melanocytic nevi (CMN) are present at birth. It is well known that the presence of large-sized congenital nevus in early life could predict a major risk of developing melanoma. OBJECTIVE To investigate the clinical and dermoscopic features of the CMN, to search for and highlight any differences between small-sized, medium-sized, large-sized CMN. METHODS A nonrandomized...

OBJECTIVES To describe the clinical features of a conjunctival nevus and to evaluate the lesion for changes in color and size over time. DESIGN Retrospective, observational, noncomparative case series. PARTICIPANTS Four hundred ten consecutive patients with conjunctival nevi. MAIN OUTCOME MEASURES The 2 main outcome measures were changes in tumor color and size. RESULTS Of the 410 patie...

PURPOSE To analyze the occurrence of near infrared (NIR) fluorescence in relation to NIR reflectance, blue-light-excited autofluorescence, angiograms, and funduscopy. METHODS Observational consecutive case series in patients with macular diseases. Imaging was performed with a confocal scanning laser ophthalmoscope for NIR reflectance, blue-light-excited autofluorescence, NIR fluorescence, and...

pseudoinclusions are sometimes evident and mild nuclear pleomorphism is typical. Mitoses are either absent or extremely infrequent. By definition dendritic cells are said not to be seen in this lesion. The growth pattern often presents a plexiform appearance, fascicles of nevus cells following the dermal appendages and neurovascular bundles. Perineural or endoneural extension is a very common f...

BACKGROUND Blue nevi that arise from the Müllerian tract are rare melanocytic lesions. Several histopathologic variants of cellular blue nevi have been described. The angiomatoid variant is characterized by a vascular component, and is considered to be a rare variant. Few studies have explored the influence of pregnancy on melanocytic lesions. CASE A 29-year-old woman was presented with a pig...