INTRODUCTION Blood biomarkers may support early diagnosis of lung cancer by enabling pre-selection of candidates for computed tomography screening or discrimination between benign and malignant screening-detected nodules. We aimed to identify features of serum metabolome distinguishing individuals with early-detected lung cancer from healthy participants of the lung cancer screening program. ...

Abstract The impact of alcohol on the body can be investigated with NMR spectroscopy in vitro , which detect a wide range metabolites but preparing samples includes tissue biopsy. Blood sampling is less invasive, blood metabolic content might not reflect changes occurring other tissues. Thus, this study aimed to investigate liver, brain, and serum metabolism evaluate link between tissues conten...

Polycyclic aromatic hydrocarbons (PAHs) are environmental and occupational carcinogens produced by the incomplete combustion of organic materials, such as coal and petroleum product combustion, tobacco smoking, and food cooking, that may be significant contributors to the burden of cardiovascular disease in human populations. The purpose of this study was to investigate associations between ten...

Introduction: Cigarette smoking affects nitric oxide production. The aim of this study was to determine associations between tobacco smoke and serum nitric oxide metabolites (NOx) concentration. Methods: Serum NOx concentration was measured by the Griess method in 230 nonsmokers, 238 active, 196 passive and 29 waterpipe smokers. Subjects were selected from participants of Tehran Lipid and Gl...

Albumin is a globular protein of plasma mammalian blood participating in transport hydrophobic metabolites and drugs. Thus, studies devoted to its binding are valuable as part evaluation new potential drugs or fluorescent probes for vivo usage. Here we describe results concerning synthesis bovine serum albumin assay both silico (docking) vitro (spectrophotometric spectrofluorimetric titrations)...

introduction as pregnancy progresses, nutrient requirements of fetus and thereby ewe increases and some changes in the levels of blood metabolites including glucose, cholesterol and total protein may occur. during gestation, maternal tissues contribute to supplying energy that required for fetus resulting in changes of ewe blood metabolites; however other factors such as breed, age, feeding typ...

This study was carried out to evaluate the effects of Satureja khuzistanica essential oils (SKEO) on performance, serum metabolites and differential counts of white blood cells in broiler chickens. A total of 280 one-day-old straight-run Cobb 500 broiler chickens were allocated into seven treatment groups with four replicates of 10 birds each from day 1 to 42 of age. The birds were continuously...

Blood is one of the most used biofluids in metabolomics studies, and the serum and plasma fractions are routinely used as a proxy for blood itself. Here we investigated the association networks of an array of 29 metabolites identified and quantified via NMR in the plasma and serum samples of two cohorts of ∼1000 healthy blood donors each. A second study of 377 individuals was used to extract pl...

to evaluate the effects of garlic on some blood metabolites in pre-partum dairy goats, the ration was supplemented with raw garlic at the doses of 0, 30, 50 and 70 g kg-1 of dry matter (dm) in eight pregnant mahabadi breed goats (59 ± 1 kg initial live weight) in a replicated latin square design during the last two months of pregnancy. each experimental period lasted 14 days with the first 12 d...