We propose a design principle that extends Murray's original optimization principle for vascular architecture to account for complex blood rheology. Minimization of an energy dissipation function enables us to determine how rheology affects the morphology of simple branching networks. The behavior of various physical quantities associated with the networks, such as the wall shear stress and the...

INTRODUCTION vascular risk factors and diseases can negatively impact cognitive function. Determinants of blood flow are implicated in thrombogenesis and ischaemic events, yet little is known about their relationship with cognition. METHODS blood rheology data were collected in 1987/88, and cognitive testing was performed in 1998/99 when the mean (+ or - standard deviation) age of the study s...

Recently it has been hypothesized that leukocyte rheology could be a relevant variable of the microcirculation during cerebral ischemia. However, relatively few studies have been carried out on the rheologic behavior of leukocytes in vascular diseases. This study aimed at quantifying the filterability through Nuclepore filters (mean pore diameter 5 microns) of both leukocyte subpopulations and ...

Several advances have taken place since the early 2000s in the field of blood flow modelling. These advances have been driven by the development of assist devices such as Left Ventricular Assist Devices (LVADs), etc., and by the acceptance of in silico tests for the generation of hypotheses concerning clot formation and lysis. We give an overview of the developments in modelling of blood rheolo...

To elucidate the basis for the drop in pressure from large artery to vein, Jean Léonard Marie Poiseuille (1797-1869) undertook a series of seminal studies that defined the laws of fluid flow in tubes of uniform cross-section and that identified the microcirculation as the major site of the resistance to flow [1, 2]. While best known for his meticulous experimental studies of viscous flow in gla...

Purpose: This study aimed to clarify the contributing factors for whole blood rheological status in female patients with hypercholesterolemia. Methods: A total of 257 untreated female patients with hypercholesterolemia and 100 normolipidemic subjects with no history of cardiovascular events were enrolled. Blood passage time (BPT) was used as a marker of whole blood rheology and was measured wit...

The current study is based on an examination of the effect Newtonian blood flow value wall shearing stress intracranial aneurysm using computational fluid dynamics. Blood frequently thought to behave like a in cerebral arteries. It fully described how saccular affects model blood-silver (Ag) nanofluid via artery. regarded as because its rheology. Newtonian, laminar, incompressible, viscous, and...

OBJECTIVE Computational fluid dynamics (CFD) simulations of intracranial aneurysm hemodynamics usually adopt the simplification of the Newtonian blood rheology model. A study was undertaken to examine whether such a model affects the predicted hemodynamics in realistic intracranial aneurysm geometries. METHODS Pulsatile CFD simulations were carried out using the Newtonian viscosity model and ...