A parametric finite element model of an osteocyte lacuna was developed to predict the microstructural response of the lacuna to imposed macroscopic strains. The model is composed of an osteocyte lacuna, a region of perilacunar tissue, canaliculi, and the surrounding bone tissue. A total of 45 different simulations were modeled with varying canalicular diameters, perilacunar tissue material modu...

A lacuna is an area of infarction within the territory of a single perforated artery. Lacuna patients may present with numerous clinical syndromes. Lacunae typically present with highly focal brain symptoms (1). The clinical expression of lacunar infarcts is related to their location. Lacunae are more frequent in the basal ganglia, internal capsule, pons, and corona radiate (1); therefore, cort...

BACKGROUND The incidence of serious complications after augmentation mammaplasty with injection of polyacrylamide hydrogel (PAAG) was high. OBJECTIVE To design a new method for healing of the cavities and cysts after augmentation mammaplasty. METHODS 102 patients in whom PAAG exceeded the breast and spread to the thoracic-abdominal walls were enrolled and divided into two groups. RESULTS ...

According to Hempel’s paradox, evidence (E) that an object is a nonblack nonraven confirms the hypothesis (H) that every raven is black. According to the standard Bayesian solution, E does confirm H but only to a minute degree. This solution relies on the almost never explicitly defended assumption that the probability of H should not be affected by evidence that an object is nonblack. I argue ...

We fill a lacuna in the literature by giving a version in dimension 1 of the Relative Hurewicz Theorem, and relate this to abelianisations of groupoids, covering spaces, covering morphisms of groupoids, and Crowell’s notion of derived modules.

Indicators are increasingly recognized as an important decision aid tool to translate sustainability issue from theory into practice. However, indicator development for sustainable community development is rather successful than the agricultural sector due to methodological lacuna. The aim of this study is to develop a methodological framework for indicator development and an essential set of i...

Chloride channels play important roles in the plasma membrane and in intracellular organelles. Mice deficient for the ubiquitously expressed ClC-7 Cl(-) channel show severe osteopetrosis and retinal degeneration. Although osteoclasts are present in normal numbers, they fail to resorb bone because they cannot acidify the extracellular resorption lacuna. ClC-7 resides in late endosomal and lysoso...