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abstract  introduction: during extrinsic coagulation pathway, a complex is developed between factor vii, calcium and tissue factor (a cell membrane lipoprotein that is exposed after cell injury). factor vii needs calcium and vitamin k for its biologic activation. coronary artery disease (cad) can be induced by increased level and activity of the coagulation factors vii, viii and ix. in postmeno...

Stroke and Blood Coagulation • A study of the coagulation parameters of 87 normal controls (ages 50 to 80) were compared with those of 33 patients with thrombotic stroke and 55 patients with diabetes mellitus of the same age distribution. There were no significant differences when tested for the influence of sex or age. Twenty-seven tests of clotting were done on each specimen, a total of 4,725...

Editor: STANFORD WEssLu, M.D.

Objective(s): Haemostasis prevents blood loss following vascular injury. It depends on the unique concert of events involving platelets and specific blood proteins, known as coagulation factors. The clotting system requires precise regulation and coordinated reactions to maintain the integrity of the vasculature. Clotting insufficiency mostly occurs due to genetically inherited coagulation fact...

objective(s): haemostasis prevents blood loss following vascular injury. it depends on the unique concert of events involving platelets and specific blood proteins, known as coagulation factors. the clotting system requires precise regulation and coordinated reactions to maintain the integrity of the vasculature. clotting insufficiency mostly occurs due to genetically inherited coagulation fact...

Description is given of changes in blood coagulability found in diseases of the rabbit, including malignant tumor, spontaneous infections, non-bacterial diseases and lesions, and hemorrhagic states specifically induced. The changes involved variously the time of onset of blood coagulation, clot formation rate and the rate and extent of clot retraction.

Although calcium is essential for the formation of thrombin, it can be recovered quantitatively from formed horse thrombin without affecting its coagulating activity. Citrate also has no significant effect. As stated in the text, this does not exclude the possibility that thrombin is actually a calcium compound present in minute concentration; but confirming the results of Hammarsten, it does s...

Bacterial endotoxins and antigen-antibody aggregates activate complement, accelerate blood coagulation, and are implicated in intravascular blood clotting (1-7). Tha t their effect on blood coagulation proceeds through the activation of the complement system has been suspected bu t has never been shown. We have found that these and other complement-activating materials initiate blood coagulatio...