The cerebral endothelium is an active interface between blood and the central nervous system. In addition to being a physical barrier brain, also actively regulates metabolic homeostasis, vascular tone permeability, coagulation, movement of immune cells. Being part blood–brain barrier, endothelial cells brain have specialized morphology, physiology, phenotypes due their unique microenvironment....

Citation: Zhao H, Zhang K, Tang R, Meng H, Zou Y, Wu P, Hu R, Liu X, Feng H and Chen Y (2018) TRPV4 Blockade Preserves the Blood–Brain Barrier by Inhibiting Stress Fiber Formation in a Rat Model of Intracerebral Hemorrhage. Front. Mol. Neurosci. 11:97. doi: 10.3389/fnmol.2018.00097 TRPV4 Blockade Preserves the Blood–Brain Barrier by Inhibiting Stress Fiber Formation in a Rat Model of Intracereb...

The complex interaction between an ultrasound-driven microbubble and an enclosing capillary microvessel is investigated by means of a coupled, multidomain numerical model using the finite volume formulation. This system is of interest in the study of transient blood-brain barrier disruption (BBBD) for drug delivery applications. The compliant vessel structure is incorporated explicitly as a dis...

Organs-on-chips are a new class of microengineered laboratory models that combine several of the advantages of current in vivo and in vitro models. In this review, we summarize the advances that have been made in the development of organ-on-chip models of the blood-brain barrier (BBBs-on-chips) and the challenges that are still ahead. The BBB is formed by specialized endothelial cells and separ...

Objective(s): To investigate the effect of Ginkgo biloba extract EGb761 in early brain injury (EBI) after subarachnoid hemorrhage (SAH) and its mechanism. Materials and Methods: The SAH rat model was constructed and pre-treated with EGb761.The neurological function, severity of SAH, water content of brain tissue, damage degree of the blo...

Glioblastoma multiforme (GBM) is one of the most aggressive malignant brain tumors and urgently requires development new therapeutic strategies. In this study, an innovative hybrid in vitro vascularized GBM-on-a-chip model presented as a strategic integration microfluidics 3D bioprinting technologies. The system can recreate compartmentalized tumor microenvironment, comprising functional blood ...

Alcohol abuse causes progressive toxicity and degeneration in liver and brain due to insulin resistance, which exacerbates oxidative stress and pro-inflammatory cytokine activation. Alcohol-induced steatohepatitis promotes synthesis and accumulation of ceramides and other toxic lipids that cause insulin resistance. Ceramides can readily cross the blood-brain barrier, and ceramide exposure cause...

Introduction: Recent studies have reported that the Aloe vera (Aloe barbadensis miller) plant has anti-inflammatory and antioxidant effects. This study evaluated the neuroprotective effects of different doses of Aloe vera extract after traumatic brain injury (TBI) in male rats. Materials and Methods:  In this study, 70 male rats were divided into 2 groups; each group consists of 5 of sub-g...