A cellular bleb grows when a portion of the cell membrane detaches from the underlying cortex under the influence of a cytoplasmic pressure. We develop a quantitative model for the growth and dynamics of these objects in a simple two-dimensional setting. In particular, we first find the minimum cytoplasmic pressure and minimum unsupported membrane length for a stationary bleb to nucleate and gr...

PURPOSE The aim of this study is to investigate whether CS-g-MMCs conjugate (CSM) could be a new agent to prevent the post-operative fibrosis in a rabbit model of experimental glaucoma filtration surgery. MATERIALS AND METHODS In a randomized, controlled, masked-observer study, 40 New Zealand White rabbits underwent trabeculectomy in the right eyes and randomly received subconjunctival inject...

AIMS/BACKGROUND The introduction of the adjunctive use of antiproliferatives to trabeculectomy has greatly improved the success rate of this operation. Trabeculectomy with antiproliferative treatment, however, is usually associated with a cystic and thin walled filtering bleb, which may be more susceptible to infection. The objective of this study was to evaluate the incidence, clinical finding...

purpose : to evaluate usefulness of anterior segment optical coherence tomography (as-oct) in evaluation of filtering bleb functionality and to correlate its findings with clinical bleb examination methods : in this cross-sectional, descriptive study 55 eyes with apparently functional bleb were evaluated. following a comprehensive ophthalmic examination, filtering bleb grading was performed bas...

OBJECTIVE Comparison of fornix- and limbus-based conjunctival flaps with respect to cystic bleb-related complications of trabeculectomy with high-dose mitomycin C (MMC) in pediatric and young adult glaucoma. DESIGN Retrospective nonrandomized comparative interventional case series. PARTICIPANTS Thirty-seven patients. METHODS Identification of patients aged <30 years from operating theater...

PURPOSE To evaluate the influence that vitreous incarceration may exert on the presence of postoperative conjunctival blebs over sclerotomies after transconjunctival sutureless vitrectomy (TSV). Blebs are formed by incisional leakage due to incompetent closure. METHODS Experimental study in which 23-gauge TSV was performed in 146 cadaveric pig eyes. Once the vitrectomy was finished, triamcino...

PURPOSE Postoperative subconjunctival wound healing remains the commonest cause of late bleb failure after glaucoma filtration surgery. This study was undertaken to investigate whether the human monoclonal antibody that neutralizes transforming growth factor-beta2 (CAT-152; lerdelimumab) could be used as a postoperative agent to prevent scarring after glaucoma surgery and compared it with 5-flu...

Trabeculectomy remains the standard surgery for intraocular pressure control for glaucoma. It involves a full thickness penetration of sclera, to allow aqueous seepage to subconjunctival space under a scleral flap. However, it carries the risk of serious bleb related complications like overfiltration, hypotony and consequent persistent choroidal detachment, shallow anterior chamber, cataract, p...

PURPOSE To compare the efficacy and safety of topical mitomycin-C (MMC) drops with that of subconjunctival 5-fluorouracil (5-FU) injections for management of early bleb failure after trabeculectomy or combined phacoemulsification and trabeculectomy with posterior chamber intraocular lens implantation (PT+PCIOL). METHODS In a randomized comparative study, 37 eyes of 37 patients with impending ...