Carbapenemases production, either metallo-lactamases (MBLs), KPC or oxacillinases (OXA), is the main resistance mechanism responsible for resistance phenotype to carbapenems in Acinetobacter.1 While for MBLs and KPCs there are some screening tests for their detection,2,3 the same is not true for oxacillinases. During the investigation of a large outbreak, we analyzed 584 carbapenem-resistant Ac...

Metallo-β-lactamase (MBL)-producing gram-negative bacteria are an increasing public health concern worldwide. Screening tests for the rapid and specific identification of these pathogens are essential, and should be included among routine diagnostics in laboratories. This study aimed to determine the MBL frequency among carbapenem-resistant Pseudomonas aeruginosa isolates, and to evaluate the a...

Background: Due to the increasing antibiotic resistance, treating infections caused by Klebsiella pneumoniae has become more challenging. Objectives: The present study aimed investigate prevalence of blaOXA-48 and blaNDM producing carbapenem-resistant K. isolated from clinical samples in Shahid Rajaei hospital Tehran, Iran. Methods: Various were collected 1,186 patients admitted with open heart...

An investigation was carried out into the genetic mechanisms responsible for multidrug resistance in nine carbapenem-resistant Pseudomonas aeruginosa isolates from different hospitals in Recife, Brazil. Susceptibility to antimicrobial agents was determined by broth microdilution. Polymerase chain reaction (PCR) was employed to detect the presence of genes encoding β-lactamases, aminoglycoside-m...

BACKGROUND Pseudomonas aeruginosa commonly causes nosocomial bloodstream infections and the emergence of a variety of β-lactamases (BLs) is worrying. In 5 hospitals in Belo Horizonte, Brazil, the presence of phenotypes encoding BL genes was established and the genetic diversity of the P. aeruginosa strains recovered from bloodstream infections was analyzed. MATERIALS AND METHODS The isolates ...

The bacterial factors associated with bacteremia by multidrug-resistant and extensively drug-resistant P. aeruginosa, including overexpression of efflux pumps, AmpC overproduction, and loss/alteration of the OprD porin in isolates that are non-Metallo-β-Lactamase producing were analyzed in a retrospective study. Molecular analyses included strain typing by Pulsed Field Gel Electrophoresis and i...

background and objectives : carbapenem resistant pseudomonas aeruginosa is a serious cause of nosocomial infections.the main purpose of the study is to determine the prevalence rate of imipenem resistant pseudomonas aeruginosa carrying metallo- beta- lactamase (mbl) genes. material and methods : 236 pseudomonas aeruginosa isolates were collected from teaching hospitals of ahvaz university of me...

introduction recently acinetobacter baumannii isolates have emerged as a problematic infectious agent that causes meningitis in neurosurgical patients. colistin has been used successfully for the treatment of a. baumannii meningitis but colistin resistant isolates have been reported worldwide. case presentation two isolates of a. baumannii were cultured during a five-day period from cerebrospin...

Pseudomonas aeruginosa is an opportunistic pathogen that causes frequently nosocomial infections, currently becoming more difficult to treat due to the various resistance mechanisms and different virulence factors. The purpose of this study was to determine the risk factors independently associated with the development of bacteremia by carbapenem-resistant P. aeruginosa, the frequency of virule...