نتایج جستجو برای: bladder cancer cell line 5637

تعداد نتایج: 2636310  

2012
Jie Li Junlei Zhang Yang Liu Gang Ye

BACKGROUND Xeroderma pigmentosum group F (XPF) is an important participant in the nucleotide excision repair process. This study aimed to investigate the expression of DNA repair gene xeroderma pigmentosum group F (XPF) in bladder cancer and its clinical significance. MATERIAL/METHODS Total RNA and protein were extracted from 45 untreated bladder cancer tissues and 21 hydroxycamptothecin (HCP...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2011
Jaqueline C Oliveira María S Brassesco Andressa G Morales Julia A Pezuk Paola Fernanda Fedatto Glenda N da Silva Carlos A Scrideli Luiz G Tone

Bladder carcinoma is one of the most common tumors in the world and despite the therapy currently available most of the patients relapse. Better understanding of the factors involved in disease pathogenesis would provide insights for the development of more effective strategies in treatment. Recently, differential miRNA expression profiles in bladder urothelial carcinomas identified miR-100 dow...

Journal: :journal of cell and molecular research 0
hajar aryan zahra-soheila soheili

there exists an association between pi3k pathway licentious activity and the considerable feature of high metastatic potential of the genitourinary cancer cells. although du 145 and 5637 have functional phosphatase and tensin homolog (pten) tumor suppressor gene, which antagonizes pi3k function, pc-3 is null for pten gene. in pursuit to explain why pten bearing cell lines display high metastati...

2016
Takashi Kawahara Satoshi Inoue Hiroki Ide Eiji Kashiwagi Shinji Ohtake Taichi Mizushima Peng Li Yi Li Yichun Zheng Hiroji Uemura George J. Netto Hitoshi Ishiguro Hiroshi Miyamoto

The expression status of ZKSCAN3, a zinc-finger transcription factor containing KRAB and SCAN domains, as well as its biological significance, in human bladder cancer remains largely unknown. In the current study, we aimed to determine the functional role of ZKSCAN3 in bladder cancer progression. Immunohistochemistry in tissue specimens detected ZKSCAN3 signals in 138 (93.2%) of 148 urothelial ...

2015
Yonghao Zhan Yuchen Liu Junhao Lin Xing Fu Chengle Zhuang Li Liu Wen Xu Jianfa Li Mingwei Chen Guoping Zhao Weiren Huang Zhiming Cai

Ribonucleic acid interference (RNAi) based on microRNA (miRNA) may provide efficient and safe therapeutic opportunities. However, natural microRNAs can not easily be regulated and usually cause few phenotypic changes. Using the engineering principles of synthetic biology, we provided a novel and standard platform for the generation of tetracycline (Tet)-inducible vectors that express artificial...

2017
Junhao Lin Yonghao Zhan Yuchen Liu Zhicong Chen Jianbo Liang Wei Li Anbang He Liqun Zhou Hongbin Mei Feng Wang Weiren Huang

Bladder cancer is one of the most common urinary cancers worldwide. Emerging studies indicated that long non-coding RNAs (lncRNAs) play crucial roles in cancer biology. In this study, we found that a novel lncRNA Zinc finger E-box-binding homeebox1 (ZEB1) antisense RNA (ZEB1-AS1) was overexpressed in bladder cancer tissues compared to paired noncancerous tissues. Moreover, the expression of ZEB...

2018
Ke-Wang Luo Wing-Yin Lung Chun-Xie Xin-Le Luo Wei-Ren Huang

Epigallocatechin-3-gallate (EGCG), the bioactive polyphenol in green tea, has been demonstrated to have various biological activities. We previously found that EGCG inhibited SW780 tumor growth by down-regulation of NF-κB and MMP-9. This study demonstrated that EGCG inhibited bladder cancer T24 and 5637 cell proliferation and migration via PI3K/AKT pathway, without modulation of NF-κB. Our resu...

2015
Ye Lei Bin Li Shiyu Tong Lin Qi Xiheng Hu Yunbo Cui Zengbo Li Wei He Xiongbing Zu Zhi Wang Minfeng Chen

BACKGROUND The microRNA miR-101 is downregulated in several cancers, including bladder cancer. However, miR-101's role in the invasion, metastasis, and chemosensitivity of bladder cancer cells remains unclear. This study was conducted to determine miR-101's role on the lymphangiogenic molecule vascular endothelial growth factor C (VEGF-C) and their effects upon bladder cancer cell migration, in...

پایان نامه :دانشگاه تربیت معلم - تهران - دانشکده زیست شناسی 1391

بررسی تآثیر کورکومین بر بیان آکواپورین5 در سلول های سرطانی روده بزرگ انسان(ht-29) سرطان روده بزرگ جزو بیماری های خطرناک بوده و از نظر شیوع سومین سرطان شایع و دومین علت مرگ ومیر ناشی از سرطان در جهان محسوب می شود. خطرابتلا به این سرطان تحت تاثیر دو عامل محیطی وفاکتورهای ژنتیکی می باشد. آکواپورین ها، پروتئین های کانال آبی بوده که نقش مهمی را در انتقال آب در بافتهای اندوتلیالی و اپی تلیالی بر عهد...

2016
Jinbo Chen Long Wang Yunhua Tang Guanghui Gong Longfei Liu Minfeng Chen Zhi Chen Yu Cui Chao Li Xu Cheng Lin Qi Xiongbing Zu

BACKGROUND Maspin, a non-inhibitory member of the serine protease inhibitor superfamily, has been characterized as a tumor suppressor gene in multiple cancer types. Chemotherapeutic insensitivity is one of major obstacles to effectively treating muscle invasive bladder cancer (MIBC). This study was conducted to investigate the role and probable mechanism of Maspin enhancing cisplatin chemosensi...

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