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تعداد نتایج: 55711 فیلتر نتایج به سال:
BACKGROUND Treatment for patients with advanced non-small cell lung cancer (NSCLC) is often determined by the presence of biomarkers that predict the response to agents targeting specific molecular pathways. Demands for multiplex analysis of the genes involved in the pathogenesis of NSCLC are increasing. METHODS We validated the Ion Torrent Personal Genome Machine (PGM) system using the Ion A...
Cryptosporidium is an important enteric pathogen that infects a wide range of humans and animals. Rapid and reliable detection and characterisation methods are essential for understanding the transmission dynamics of the parasite. Sanger sequencing, and high-throughput sequencing (HTS) on an Ion Torrent platform, were compared with each other for their sensitivity and accuracy in detecting and ...
Gastric cancer is the one of the major causes of cancer-related death, especially in Asia. Gastric adenocarcinoma, the most common type of gastric cancer, is heterogeneous and its incidence and cause varies widely with geographical regions, gender, ethnicity, and diet. Since unique mutations have been observed in individual human cancer samples, identification and characterization of the molecu...
introduction: excessive temperature rise during drilling of the mandible for dental implant placement might damage adjacent osseous tissues. various factors affect temperature rise, including the geometrical parameters of surgical drills, one of which is the drill bit head angle. the aim of this research was to determine suitable drill bit head angle to induce minimum temperature rise during ma...
High-throughput sequencing of the taxonomically informative 16S rRNA gene provides a powerful approach for exploring microbial diversity. Here we compare the performances of two common "benchtop" sequencing platforms, Illumina MiSeq and Ion Torrent Personal Genome Machine (PGM), for bacterial community profiling by 16S rRNA (V1-V2) amplicon sequencing. We benchmarked performance by using a 20-o...
Molecular docking modelling was performed as previously described (Torrent et al., 2011). Briefl y, the docking simulations were performed using Autodock 4.2 (The Scripps Research Institute, La Jolla, CA, USA). The protein coordinates of the eight human RNases were taken from X-ray crystallography or NMR data. When no three-dimensional structure was available, the protein structures were predic...
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