Recent literature shows an association between long-term bisphosphonate therapy and low-energy fractures of the subtrochanteric femur. It is thought that the pharmacology of bisphosphonates and stress characteristics of the subtrochanteric femur predispose patients on long-term therapy to fracture. There are few reports in the literature of bisphosphonate-associated periprosthetic fractures wit...

Bisphosphonates are the most widely prescribed pharmacologic treatment for osteoporosis and reduce fracture risk in postmenopausal women by up to 50%. However, in the past decade these drugs have been associated with atypical femoral fractures (AFFs), rare fractures with a transverse, brittle morphology. The unusual fracture morphology suggests that bisphosphonate treatment may impair toughenin...

Osteosarcoma is amongst the most common primary malignant tumors of bone and occurs in adolescents and young adults. Current treatment is a combination of both surgery and chemotherapeutics. However, the use of anticancer drugs is still associated with serious side effects. In this article we describe a doxorubicin drug delivery system based on bisphosphonate nanoparticles with a narrow size di...

BACKGROUND The main objective of our study was to identify oral symptoms and signs most likely to be associated with the exposure of necrotic bone in bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIAL AND METHODS The study group consisted of 183 patients with BRONJ. We recorded data on the underlying disease, bisphosphonate used, location of osteonecrosis, symptoms, pain, fistu...

BACKGROUND Oral bisphosphonates are commonly used to prevent / treat osteoporosis. However, bisphosphonate treatment is not without risk and serious adverse effects, including upper gastrointestinal bleeding (UGIB) have been described. We sought to determine if new users of bisphosphonate drugs were more likely to suffer a serious UGIB within 120 days of drug initiation. METHODS This was a po...

This paper discusses extensions to the language Ei el, required to write more comprehensive software speci cations, where a speci cation in Ei el is a collection of class interfaces with features speci ed using an assertion language (i.e. a BON static model). The focus of the paper is the extension of the assertion language with quanti cation. Two forms of quanti cation are identi ed, which are...

AIM OF THE STUDY Post-radiogenic osteonecrosis of the mandible is a serious complication in patients with combined treated head/neck tumors. Osteonecrosis of the mandible can also occur following administration of bisphosphonates. In the present article we would like to present our experiences over the last five years in treating both bisphosphonate-associated osteonecrosis and osteoradionecros...

BACKGROUND Estimations of the risk of bisphosphonate associated atypical femoral fractures vary between different population-based studies, from considerable to neglectable. A possible explanation for these discrepancies could be different definitions of atypical fractures. We aimed to identify specific radiographic fracture characteristics associated with bisphosphonate use. METHODS In a pre...

BACKGROUND AND PURPOSE External fixation pins tend to loosen with time, especially from cancellous bone. A coating that releases a bisphosphonate has been shown to improve the fixation of dental implants in humans. We now tested a bisphosphonate coating on steel pins for external fixation. The primary hypothesis was that coated pins would be better fixed in the diaphysis. METHODS 20 patients ...

here has been an exponential rise in the literature of osteonecrosis and its complications in patients taking bisphosphonate drugs. Despite this ncrease, there is little evidence-based publications on how best to manage this complication. In this article (the first of two on bisphosphonate elated jaw complications), we compare the guidelines produced by national specialist medical associations ...