Fluorous diastereomeric mixture synthesis (FDMS) is introduced and demonstrated in the synthesis of six diastereomers of hydantoin-fused hexahydrochromeno[4,3-b]pyrroles.

Methoxymethylation of a variety of alcohols was performed using formaldehyde dimethyl acetal in the presence of 1,3-dichloro-5,5-dimethyl hydantoin [DCDMH] and Poly N,N′-dibromo-N-ethyl naphthyl-2,7-disulfonamide [PBNS] as catalysts at room temperature and under solvent-free conditions. Our experiments show that primary and secondary alcohols can be smoothly converted into the corresponding MOM...

A mild and efficient one-pot three-component and environmentally benign approach for the synthesis of a wide range of hydantoin annulated derivatives has been described. A multi-component reaction between a carbonyl compounds (ketone or aldehyde), potassium cyanide and ammonium carbonate (as cyanating agent and amine source, respectively leads to the formation of hydantoins. The proposed optimi...

The title compound is a hydantoin derivative that has been synthesized through three-component reaction of ethyl pyruvate, p-anisidine and phenyl isocyanate. This paper provides comprehensive spectral dataset for the compound, including 1H 13C{1H} NMR, IR, HRMS, X-ray crystallography analyses. A tentative mechanism comprising two complementary pathways provided based on additional experiments w...

BACKGROUND Multidrug resistance (MDR) is one of the major concerns in the treatment of cancer and one of the major causes of therapy failure. The overexpression of an ABC transporter, the ABCB1, is often associated with MDR in cancer. Previously it was observed that hydantoin compounds can modulate the activity of the ABCB1 pump. MATERIALS AND METHODS Fourteen hydantoin derivatives were synth...

Thirteen years ago, without any pharmacological interests particularly, we have reported on preparations, electronic and crystal structures of a copper(II) complexes having 5,5-diphenylhydantoinate (phenytoinate; deprotonated phenytoin) and 2-phenylethylamine (phenethylamine) ligands (Figure 1) [1]. Before this paper, I (mainly supervised by the late Dr. Seiko Komorita at Osaka university, Japa...