Recently developed perfusion micro-bioreactors offer the promise of more physiologic in vitro systems for tissue engineering. Successful application of such bioreactors will require a method to characterize the bioreactor environment required to elicit desired cell function. We present a mathematical model to describe nutrient/growth factor transport and cell growth inside a microchannel biorea...

Several bioreactor systems are used for biological treatment of hydrogen sulfide. Among these, airlift bioreactors are promising for the bioconversion of hydrogen sulfide into elemental sulfur. The performance of airlift bioreactors is not adequately understood, particularly when directly fed with hydrogen sulfide gas. The objective of this paper is to investigate the performance of an airlift ...

The aim of the present work is to design and construct an ex vivo bioreactor system to assess the real time viability of vascular tissue. Porcine carotid artery as a model tissue was used in the ex vivo bioreactor setup to monitor its viability under physiological conditions such as oxygen, pressure, temperature, and flow. The real time tissue viability was evaluated by monitoring tissue metabo...

Rahul Kumar, Junior, Columbia University Mentors: Sharan Ramaswamy Ph.D., University of Pittsburgh Michael Sacks Ph.D. University of Pittsburgh Introduction: A bioreactor that is capable of cyclic flexure, stretch, and flow (FSF) has been previously designed and built by Engelmayr et al [1]. The bioreactor is used to implement mechanical stimuli on engineered heart valve tissue [2]. In this mec...

Continuous production of nisin in laboratory media and whey permeate was investigated using a packed-bed bioreactor. Lactococcus lactis subsp. lactis ATCC 11454 was immobilized by natural attachment to fibre surfaces and entrapment in the void volume within spiral wound fibrous matrix. The inoculated bioreactor was fed M17 medium and effect of pH, temperature, dilution rate, and substrate conce...

The occurrence of simultaneous partial nitrification, anaerobic ammonium oxidation and denitrification (SNAD) observed in a single partially aerated full-scale bioreactor treating landfill-leachate is reported in this paper. At present, the full-scale bioreactor is treating an average leachate flow of 304 m(3)d(-1) with a sludge retention time between 12 and 18d. The average COD, NH(4)(+)-N and...

Small-diameter (<4 mm) vascular constructs are urgently needed for patients requiring replacement of their peripheral vessels. However, successful development of constructs remains a significant challenge. In this study, we successfully developed small-diameter vascular constructs with high patency using our integrally designed computer-controlled bioreactor system. This computer-controlled bio...

Glossary batch process A technique in which all nutrients for the microorganisms are added to the bioreactor only once and the products are separated in their entirety when the fermentation process is completed. bioreactor or fermenter The culture vessel or system used for growing microorganisms and producing microbial metabolic products such as lactic acid. continuous process A technique in wh...

The ammonia and phosphorus removal efficiencies of the microalgae Chlorella vulgaris and Scenedesmus dimorphus, during biotreatment of secondary effluent from an agroindustrial wastewater of a dairy industry and pig farming, were evaluated. The microalgae were isolated from a wastewater stabilization pond near Santafé de Bogota, Colombia. Batch cultures were made using both species in 4-l cylin...