Bridging superstructures added to small azamacrocycles, through the accompanying additional topological constraint, enhance the characteristic that makes azamacrocycles indispensable ligands for transition metal coordination including biomimetic chemistry: high complex stability. This review begins by briefly revisiting the coordination chemistry concepts leading to this advantage over less top...

We report the first biomimetic syntheses of (-)-gochnatiolides A-C and (-)-ainsliadimer B based on our proposed biogenetic pathway. Our synthesis features one-pot cascade transformations including Saegusa oxidation, intermolecular Diels-Alder cycloaddition, and radical-mediated allylic oxidation, which allow for the rapid generation of (-)-gochnatiolides A-C in a collective manner. We also disc...

Diabetes is a rapidly growing disease that can be monitored at an individual level by controlling the blood glucose level, hence minimizing the negative impact of the disease. Significant research efforts have been focused on the design of novel and improved technologies to overcome the limitations of existing glucose analysis methods. In this context, nanotechnology has enabled the diagnosis a...

A biomimetic synthetic strategy has resulted in a two-step total synthesis of (±)-ulodione and the prediction two potential natural products, (±)-ulodiones C D. This work was guided by computational investigations into selectivity proposed biosynthetic Diels–Alder dimerization, which then utilized chemical synthesis. highlights how considerations can both guide design efficient strategies lead ...

In the past two decades, use of biomolecules, either from biological or biomimetic systems (or so-called synthesis), has emerged as a promising green approach to synthesize gold nanomaterials (Au NMs). Here, we describe recent progress on and syntheses Au NMs. We focus our discussions selection principles synthesis mechanisms involving evolution synthesis, contributions bioinspired production h...

A convergent biomimetic synthesis of hemibrevetoxin B from d-glucal and d-arabinose utilizes an electrophile-promoted cascade anti-Baldwin cyclization of an epoxy alcohol. The epoxy alcohol arises from a palladium-catalyzed coupling of a highly functionalized organozinc compound and an alkenyl iodide, which serve as two chiral building blocks of similar size and complexity. This first successfu...