WF14865Aand B, novel cathepsins B and L inhibitors, were produced and isolated separately from the culture mycelium of a fungal strain Aphanoascus fulvescens No. 14865. Spectroscopic analysis revealed that both WF14865Aand B were composed of transepoxysuccinyl moieties, 1 -//-imidazole-2-ylamine, and isoleucine or leucine. These compounds inhibited human cathepsins B and L with IC50 values in t...

“Efficiency” is a poorly defined and generally overused term in livestock production. The segmentation present in the beef industry provides wide latitude for limited, and potentially conflicting, definitions and makes achievement of an industry-wide consensus on the definition of efficiency difficult. Much of what we believe today about efficiency of animal production was introduced by Dickers...

A major route for hydrogen production by purple photosynthetic bacteria is biological nitrogen fixation. Nitrogenases reduce atmospheric nitrogen to ammonia with the concomitant obligate production of molecular hydrogen. However, hydrogen production in the context of nitrogen fixation is a rather inefficient process because about 75% of the reductant consumed by the nitrogenase is used to gener...

In oxygenic photosynthesis, a highly oxidising chlorophyll species strips electrons out of two water molecules, generating molecular oxygen as a waste product. A recent study has provided new insights into the structure of the molecular machinery responsible for biological oxygen production.

A cross-flow membrane was coupled to a chemostat to create an anaerobic membrane bioreactor (MBR) for biological hydrogen production. The reactor was fed glucose (10,000 mg/L) and inoculated with a soil inoculum heat-treated to kill non-spore-forming methanogens. Hydrogen gas was consistently produced at a concentration of 57-60% in the headspace under all conditions. When operated in chemostat...

Recently, antimicrobial peptides have been introduced as potent antibiotics with a wide rangeof antimicrobial activities. They have also exhibited other biological activities, including antiinflammatory,growth stimulating, and anti-cancer activities. In this study, an analog of MagaininII was designed and produced as a recombinant fusion protein. The designed sequence containe...