biological cell

Determination of the relative biological effectiveness (RBE) of Auger electrons is a challenging task in radiobiology. In this study, we have estimated the RBE of internal conversion (IC) and Auger electrons released during Gadolinium neutron capture reaction (GNCR) by means of biological weighting functions (BWFs) with microdosimetric approach. Regarding the different distribution of Gadoliniu...

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synthesis and cytotoxicity study of new cyclopenta[b] quinoline-1,8-dione derivatives

Journal: :iranian journal of pharmaceutical research 0

ramin miri medicinal and natural products chemistry research center, shiraz university of medical sciences. shiraz, iran. pharmaceutical sciences research center, tehran university of medical sciences. tehran, 14174, iran omidreza firuzi medicinal and natural products chemistry research center, shiraz university of medical sciences. shiraz, iran. payam peymani medicinal and natural products chemistry research center, shiraz university of medical sciences. shiraz, iran. zohreh nazarian pharmaceutical sciences research center, tehran university of medical sciences. tehran, 14174, iran. department of medicinal chemistry, faculty of pharmacy, tehran university of medical sciences, tehran, iran. abbas shafiee pharmaceutical sciences research center, tehran university of medical sciences. tehran, 14174, iran. department of medicinal chemistry, faculty of pharmacy, tehran university of medical sciences, tehran, iran.

dna intercalators belong to aromatic heterocyclic compounds interacting reversibly with dna. these compounds have been used extremely as cytotoxic agents against cancer. in this study, the synthesis and biological activity of some novel derivatives of cyclopenta [b] quinoline-1, 8-dione as new intercalating agent were investigated. twenty novel derivatives of cyclopenta [b] quinoline-1, 8-dione...

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