background the current distribution of and access to health services along with the future health needs of the population have prompted wide application of geographic information systems (giss). during recent years, gis has been used in public health management for planning and organization of healthcare services. this study investigates geographical accessibility of residential areas in bandar...

The Web Accessibility Initiative (WAI) was established to enhance the accessibility of Web resources for people with disabilities. In this paper we argue that although WAI’s advocacy work has been very successful, the WAI approach is flawed. Rather than WAI’s emphasis on adoption of technical guidelines, the authors argue that the priority should be for a user-focussed approach, which embeds be...

It is known that chromatin features such as histone modifications and the binding of transcription factors exert a significant impact on the "openness" of chromatin. In this study, we present a quantitative analysis of the genome-wide relationship between chromatin features and chromatin accessibility in DNase I hypersensitive sites. We found that these features show distinct preference to loca...

Three monoclonal antibodies specific to the central cell-binding and the C- and N-terminal domains of fibronectin (FN) were used to test antigenic epitope accessibility on human plasma and cerebrospinal fibronectins. In the plasma group, the mean N-terminal FN domain immunoreactivity was about one fourth that of the cell-binding and C-terminal domains, whereas in cerebrospinal fluid they were n...

Accurate characterization of the mechanical behavior of soft tissues is needed for medical simulation, diagnostic, and tissue engineering purposes. Determining the complex behavior of soft tissues requires mechanical testing in their natural state. Such in vivo tests are wrought with ethical, accessibility, physiological noise, and uncontrolled boundary condition issues. Several groups have dev...

A Support Vector Machine learning system has been trained to predict protein solvent accessibility from the primary structure. Different kernel functions and sliding window sizes have been explored to find how they affect the prediction performance. Using a cut-off threshold of 15% that splits the dataset evenly (an equal number of exposed and buried residues), this method was able to achieve a...

DMSS (Discrete Metabolic Simulation System) is a framework for modelling and simulating metabolic pathways. Quantitative simulation of metabolic pathways is achieved using discrete-event techniques. The approach differs from most quantitative simulators of metabolism which employ either time-differentiated functions or mathematical modelling techniques. Instead, models are constructed from bioc...

The open source environment R isf the most widely used software to statistically explore biological data sets including sequence alignments. BAM is the de facto standard file format for sequence alignment. With rbamtools, we provide now a full spectrum of accessibility to BAM for R users such as reading, writing, extraction of subsets and plotting of alignment depth where the script syntax clos...

Integrins are major cell adhesion receptors which assume two important functions: first they act as anchoring molecules allowing firm cellular attachment to the extracellular matrix, and second they work as signalling receptors being able to transduce signals in both directions (outside-in and inside-out) through the plasma membrane. Their biological importance is determined by their involvemen...

This paper reports the results of two independent studies dealing with saliency effects within the domain of folkbiological knowledge. In Study 1 we present data from a free listing task that explored tree name generation among Tzotzil Maya of Zinacantán (Chiapas). Study 2 compares Menominee Native Americans with Majority Culture (nonprofessional) fish experts in central Wisconsin. Both studies...