نتایج جستجو برای: biolayer interferometry

تعداد نتایج: 11333  

2004
Yan Zheng

page 156 Abstract: Already proven in a wide array of industrial applications, surface acoustic wave devices (SAWs) also have been demonstrated to hold substantial potential in the biosensor arena. Currently, SAW resonators coated with a biolayer can distinguish specific biomolecules in both liquid and vapor phases. By incorporating periodic perturbations in the design of SAW delay line, we were...

Dialysis-related amyloidosis (DRA) is characterized by accumulation of amyloid β2-microglobulin (β2m) in the interstitial matrix. Matrix substances such as heparin have reportedly been strongly implicated in the pathogenesis of dialysis-related amyloidosis. In clinical setting of hemodialysis, two types of heparin, i.e., high and low molecular heparin (H.M.H. and L.M.H.) have been routinely use...

Journal: :Journal of Immunology 2023

Abstract Parainfluenza virus 3 (PIV3) remains to be a global burden infants, the elderly, and immunocompromised individuals. With no approved therapeutics or vaccines, PIV3 continues cause large portion of lower respiratory illness hospitalizations in young children. Similar other paramyxoviruses, utilizes two structural proteins, fusion (F) protein hemagglutinin-neuraminidase (HN) protein, for...

2016
Walid A. Al-Zyoud Robert MG. Hynson Lorraine A. Ganuelas Adelle CF. Coster Anthony P. Duff Matthew AB. Baker Alastair G. Stewart Eleni Giannoulatou Joshua WK. Ho Katharina Gaus Dali Liu Lawrence K. Lee Till Böcking

Mechanisms for transcription factor recognition of specific DNA base sequences are well characterized and recent studies demonstrate that the shape of these cognate binding sites is also important. Here, we uncover a new mechanism where the transcription factor GabR simultaneously recognizes two cognate binding sites and the shape of a 29 bp DNA sequence that bridges these sites. Small-angle X-...

2010
Joshua M. Costin Ekachai Jenwitheesuk Shee-Mei Lok Elizabeth Hunsperger Kelly A. Conrads Krystal A. Fontaine Craig R. Rees Michael G. Rossmann Sharon Isern Ram Samudrala Scott F. Michael

Viral fusogenic envelope proteins are important targets for the development of inhibitors of viral entry. We report an approach for the computational design of peptide inhibitors of the dengue 2 virus (DENV-2) envelope (E) protein using high-resolution structural data from a pre-entry dimeric form of the protein. By using predictive strategies together with computational optimization of binding...

2015
Hong You Geoffrey N. Gobert Pengfei Cai Rong Mou Sujeevi Nawaratna Guofu Fang Francois Villinger Donald P. McManus

To further investigate the importance of insulin signaling in the growth, development, sexual maturation and egg production of adult schistosomes, we have focused attention on the insulin receptors (SjIRs) of Schistosoma japonicum, which we have previously cloned and partially characterised. We now show, by Biolayer Interferometry, that human insulin can bind the L1 subdomain (insulin binding d...

2016
Deepthi Raveendran Sathees C. Raghavan

RAG complex consisting of RAG1 and RAG2 is a site-specific endonuclease responsible for the generation of antigen receptor diversity. It cleaves recombination signal sequence (RSS), comprising of conserved heptamer and nonamer. Nonamer binding domain (NBD) of RAG1 plays a central role in the recognition of RSS. To investigate the DNA binding properties of the domain, NBD of murine RAG1 was clon...

In this paper, we report on the design and fabrication of a low-cost phase shifter for application in phase shifting interferometry. Phase shifting interferometry is a powerful method for surface characterization. It uses interference data recorded during a series of predetermined phase shifts to recover the induced phase by the object surface. These controlled phase shifts are typically perfor...

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