Background & Aims: B.cepacia is one of the causative agents of health care associated infections which have the ability of attachment to different surfaces and biofilm formation is one of the most important virulence factors in pathogenesis of this microorganism. Nanoparticles are key components which are considered for the designing of new antimicrobial agents, no studies have been done on the...

The present work was performed to determine the impacts of commercial disinfectants against biomass, viability, and biochemical composition Salmonella enterica serovar Thyphimurium ATCC14028 biofilm. biofilm grown in microplates exposed namely sodium hypochlorite, benzalkonium chloride, chloroxylenol, dodecyl-benzene sulfonate-based disinfectants. Biofilm were determined using crystal violet as...

background: measuring of maternal serum pregnancy-associated plasma protein-a (papp-a) in first trimester can be a way for early detection of adverse prenatal outcome due to faulty placenta.objective: the aim was to determination of association between placental thickness in second trimester with low level of papp-a in first trimester.materials and methods: in this cohort study, serum papp-a of...

V. cholerae can form sessile biofilms associated with abiotic surfaces, cyanobacteria, zoo-plankton, mollusks, or crustaceans. Along with the vibrio polysaccharide, secreted proteins of the rbm gene cluster are key to the biofilm ultrastructure. Here we provide a thorough structural characterization of RbmA, a protein involved in mediating cell-cell and cell-biofilm contacts. We correlate our s...

conclusions: it can be concluded that most of a. baumannii isolates can form biofilm in microtiter plate and tube. the results also verified that most of these isolates were resistant to ciprofloxacin and imipenem. results: results showed that in tube method under shaking, 22% of clinical isolates were strong biofilm producers while 23% of them were not able to form biofilms. in this experiment...

Biofilm formation on implanted medical devices is a major source of lethal invasive infection by Candida albicans. Filamentous growth of this fungus is tied to biofilm formation because many filamentation-associated genes are required for surface adherence. Cell cycle or cell growth defects can induce filamentation, but we have limited information about the coupling between filamentation and fi...

BACKGROUND Biofilms are surface-associated microbial communities with significant environmental and medical impact. Here, we focus on an adherence mechanism that permits biofilm formation by Candida albicans, the major invasive fungal pathogen of humans. RESULTS The Als surface-protein family has been implicated in biofilm formation, and we show that Als1 and Als3 have critical but redundant ...

abstract biofilm is a complex community of microorganisms residing within a polysaccharide and/or protein matrix. biofilm can be produced by microorganisms such as bacteria and fungi. both gram positive and gram negative bacteria have this ability. resistance of biofilm to antimicrobial agents is becoming a global issue. bacterial biofilms are important in various aspects such as chronic human ...

Formation of biofilms is a major factor for nosocomial infections associated with methicillin-resistance Staphylococcus aureus (MRSA). This study was carried out to determine the ability of a fraction, F-10, derived from the plant Duabanga grandiflora to inhibit MRSA biofilm formation. Inhibition of biofilm production and microtiter attachment assays were employed to study the anti-biofilm acti...

The estuarine gram-negative rod and human diarrheal pathogen Vibrio cholerae synthesizes a VPS exopolysaccharide-dependent biofilm matrix that allows it to form a 3D structure on surfaces. Proteins associated with the matrix include, RbmA, RbmC, and Bap1. RbmA, a protein whose crystallographic structure suggests two binding surfaces, associates with cells by means of a VPS-dependent mechanism a...