We explore a new calibration-free approach to biodetection based on whispering gallery modes (WGMs) without a reference measure and relative shifts. Thus, the requirement to keep track of the sensor position is removed, and a freely moving population of fluorophore-doped polystyrene microspheres can now fulfill this role of sensing resonator. Breaking free from fixed surface-based biosensing pr...

Highly sensitive and selective label free devices for real-time identification of specific biomarkers are expected to significantly impact the biosensing field. The ability plasmonic systems confine light in nanometer volume manipulate it by tuning size, shape material features nanostructures, makes these promising candidates biomedical devices. In this work we demonstrate engineered sensing ca...

For diagnostic and therapeutic purposes an accurate determination of multiple metabolites is often required. Amperometric devices are attractive tools to quantify biological compounds due to the direct conversion of a biochemical event to a current. This review addresses recent developments in the use of multiwalled carbon nanotubes to enhance detection capability of amperometric array-based bi...

We have used liquid-gating to investigate the sensitivity of nanowire (NW)-based biosensors for application in the field of ultrasensitive biodetection. We developed an equivalent capacitance model of the biosensor system to explore the dependence of the sensitivity on the liquid-gate voltage (V(lg)), which was influenced by capacitive competition between the NW capacitance and the thin oxide c...

Abstract Lanthanide doped nanocrystals capable to emit higher energy photons under excitation with lower radiation are promising for a broad range of applications including biodetection, biosensing, and bioimaging. However, the adaptation these nanoparticles biological environment that requires good water-solubility, stability ease further functionalization still remains challenge. The applicat...

With the rapidly increasing demands for ultrasensitive biodetection, the design and applications of new nano-scale materials for development of sensors based on optical and electrochemical transducers have attracted substantial interest. In particular, given the comparable sizes of nanomaterials and biomolecules, there exist plenty of opportunities to develop functional nanoprobes with biomolec...

Microfluidicsand nanofluidics-based impedance sensors play an important role in identification of toxic industrial chemicals and pathogens in biodetection and biodefense arena. However, their efficient modeling and design continues to be a challenge. This paper presents high-fidelity models to resolve the electrokinetic transport process at the microand nano-scale and capture the critical effec...