Plasminogen is the plasma precursor of the fibrinolytic enzyme, plasmin. The activation of plasminogen isolated from various animal species by streptokinase, a protein of bacterial origin, has received considerable attention in recent years. A two-step reaction has been postulated wherein streptokmase reacts with a substance termed proactivator (1)) which is present in highest concentration in ...

Human activity is one of the main causes of the physical, chemical and biological degradation of soils. This degradation implies a change in soil quality as it involves both a decrease in productivity and changes in the ecological functions of the soil. The objective of the present study was to investigate the effect of soil use on soil biochemical properties, with the aim of providing data tha...

PERSPECTIVES AND SUMMARY .......................................................................... 534 PROTEIN COMPONENTS OF HORMONE-SENSITIVE ADENYLATE CYCLASE ............................................................................................ 535 Hormone Receptors and .4denylate Cy¢lase ............................................................ 535 Hormone Receptors Linked to Aden...

Trypanosomatid parasite infections have a devastating impact on human health. Little is known about the requirements for parasite growth during any stage of their complex, multi-host life cycle. In most eukaryotic organisms, sustained cell proliferation requires telomerase-dependent telomere length maintenance. Here we investigate the regulation and biochemical features of telomerase from Trypa...

Infectious prions propagate from peripheral entry sites into the central nervous system (CNS), where they cause progressive neurodegeneration that ultimately leads to death. Yet the pathogenesis of prion disease can vary dramatically depending on the strain, or conformational variant of the aberrantly folded and aggregated protein, PrP(Sc). Although most prion strains invade the CNS, some prion...