OBJECTIVE The need for effective 'anti-ageing' treatments, in particular for the management of photodamaged skin, prompted us to develop a novel method to identify new active ingredients. The model utilized a gene profiling study with corresponding connectivity mapping (Cmap) to identify novel anti-ageing compounds using all-trans retinoic acid (RA) as the lead compound due to its beneficial ef...

N-Propargylamines are useful synthetic scaffolds for the synthesis of bioactive molecules, and in addition, they possess important pharmacological activities. We obtained several neuroprotective chiral 1,2-amino alcohols 1,2-diamines, able to reduce by almost 70% rotenone oligomycin A-induced damage SH-SY5Y cells. Furthermore, some molecules assessed also counteracted toxicity evoked Ser/Thr ph...

Food-protein derived bioactive peptides are short amino acid chains that are inactive within the sequence of the parent protein, but can be released through hydrolysis by proteolytic enzymes. Several physiological effects have been attributed to these peptides, such as blood pressure reduction, scavenging of oxidative compounds, induction of satiety and reduction of cholesterol. Due to their ab...

This work aimed at the development of biodegradable nanocapsules as carriers of two bioactive compounds, 5-aminosalycilic acid and glycomacropeptide. Nanocapsules were produced through layer-by-layer (LbL) deposition of chitosan (CH) and alginate (ALG) layers on polystyrene nanoparticles. The bioactive compounds were incorporated on the third layer of the nanocapsules being its encapsulation ef...

A facile one step synthesis of anilino alky1-N-substituted phthalimide I is reported. The following compounds belonging to this series were made: 1. (anilino-N-ethyl) phthalimide 8 2. (3,4, 5-trimethoxy anilino-N-ethyl) phthalimide 6 3. (3,4, 5-trimethoxy anilino-N-propyl) phthalimide 7 4. N-(ethyl phthalirnido-p-amino benzoyl) glutamic acid diethyl ester 10 5. N-(propyl phthalimido-p-ami...

halophilic bacteria grow over a wide range of salt concentrations. in this study we aimed to isolate and screen out the halophilic bacteria and to determine their activity for production of the bioactive compounds. a total of 50 water, sediments and soil samples were collected from maharlu salt lake in southern region of fars-iran and subjected for isolation of the bioactive compound producing ...

Diazo compounds, boranes, and acyl imines undergo a three-component Mannich condensation reaction under catalyst-free conditions to give the anti β-amino carbonyl compounds in high diastereoselectivity. The reaction tolerates a variety of functional groups, and an asymmetric variant was achieved using the (-)-phenylmenthol as chiral auxiliary in good yield and selectivity. These β-amino carbony...

this study investigated the fatty acids profile, oxidative stability indices, and bioactive compounds of virgin and processed olive oils (leccino and frantoio cultivars). results showed that fatty acid profile of the studied oils contained mostly oleic acid followed by palmitic and linoleic acid. acid values of virgin frantoio and processed leccino were 0.78 and 0.18 mg koh/g oil, with peroxide...

Polymerisation of α-amino acid N-carboxyanhydrides (NCAs) is one the most common techniques to prepare synthetic polypeptides. Of special interest are NCAs derived from acids, L-aspartic and L-glutamic acid, since investigations have been focused on their use synthesise multiblock copolypeptides or hybrid polypeptide-polymers design excipients suitable for delivery bioactive compounds. This per...

Plant growth retardant (PGR) refers to organics that can inhibit the cell division of plant stem tip sub-apical meristem cells or primordial meristem cell. They are widely used in the cultivation of rhizomatous functional plants; such as Codonopsis Radix, that is a famous Chinese traditional herb. However, it is still unclear whether PGR affects the medicinal quality of C. Radix. In the present...