Interaction of very late antigen-4 (VLA-4) with its ligand vascular cell adhesion molecule-1 (VCAM-1) is required for central nervous system (CNS) migration of encephalitogenic T cells in relapsing experimental autoimmune encephalomyelitis (R-EAE). Anti-VLA-4 monoclonal antibody (mAb) treatment prior to EAE onset inhibits disease induction; however, treatment initiated after the appearance of c...

Background: Since alkaloids are nitrogenous compounds, the availability of nitrogen (N) is expected to play an important role in the biosynthesis and accumulation of alkaloids in plants. Nitrogen has been found to increase the content of alkaloids in some of the medicinal plants. Objective: The aim of this study was to compare the effects of nitrogen bio-fertilizers, conventional nitrogen fe...

Background: Mercury (Hg) is a hazardous metal responsible for environmental contamination and human intoxication. Methyl mercury bio-accumulation through food chain can be responsible for chronic mercury exposure of South Caspian Sea communities with a diet rich in fish. Uncertainties about exposure levels that could have damaging consequences for nervous system development of infants makes b...

biofertilizers are natural inputs that can be applied as complement or substituent of chemical fertilizers in sustainable agriculture. effects of n and p bio- and chemical fertilizers on growth indices of maize (zea mays l.) was studied on 2008 in shushtar, iran, based an as a factorial experiment based on completely randomized block design with three replications. treatments consisted four lev...

The incorporation of polymerizable cationic monomers has been attempted to generate dental resinous materials with antibacterial activity. This study tested the hypothesis that a dental adhesive containing a cationic monomer, methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB), would influence biofilm formation and gtf gene expression of Streptococcus mutans. The effect of the photo-p...

The present research aims to assess the potential use of the Norway rat, Rattusnorvegicus as a bio-indicator for lead and cadmium accumulation in 10 urban zones in Tehran, the metropolitan city, Iran. During April to May 2014 we collected twenty adult Norway rats from the different predefined zones. By referring to the air pollution data collected over 15 years, the sampling areas were detected...

Phytoremediation is a technology that uses plants for the remediation of the contaminated soils, sediments, tailings, and groundwaters. In this work, the ability of TrifoliumAlexanderium for the phytoremediation of the tailings soil in the Anjir-Tange coal washing plant was investigated. For this purpose, Trifolium sp. was cultivated in three soils consisting of the tailings dam, an agricultura...

Background & Aims of the Study: Aquatic macrophytes, given their rapid growth and high bio mass production, great potential to accumulate heavy metals in their organs. Phragmites australis as a hyper-cumulative plant plays an important role in the bioremediation. The Badavar River of Noorabad, Lorestan province, is exposed to urban wastewater and agricultural runoffs. In order to heavy metals (...

Heavy metal toxicity is one of the major current environment health problems and is potentially dangerous because of bio-accumulation through the food chain (Aycicek et al., 2008) and this can cause hazardous effects on livestock and human health (Aschner, 2002). In general, the hazardous effects of these toxic elements depends upon the dietary concentration of the element, absorption of the el...

The purpose of this work was to carry out preclinical toxicity and bio-distribution studies required for regulatory approval of a clinical trial application for Phase I clinical studies of ONCOS-102 (Ad5/3-D24-GM-CSF) for therapy of advanced cancers (NCT01598129). The study design, route of administration and dosage differs from the clinical protocol and in more detail, investigate bio-distribu...