5 year old male child presented with progressive abdominal distention, pallor, and growth failure since the age of 9 months. The foe did not respond to hematinic and required one blood transfusion for anemia. Liver and spleen were enlarged on abdominal exam. Peripheral smear showed features of haemolytic anemia and neonatal red blood cells. HPLC studies of patient revealed that father was a car...

I read with great interest the recent publication by Bayraktar et al. [1] on nitric oxide (NO) in beta thalassemia minor. in which they reached the conclusion that “These findings confirm that plasma NO levels in betathalassemia minor patients are decreased at the time of diagnosis.” Bayraktar et al. also noted the possible usefulness of NO level in assessing the prognosis and follow-up evaluat...

Minor beta thalassemia is a common condition in children. The aim of the present study was the investigation of serum tissue transglutaminase IgA level as potential celiac disease in patients with thalassemia minor. This case control study was conducted on patients with beta thalassemia minor and healthy children in the years of 2014 to 2015. A total of 300 children were enrolled and IgA and ti...

Minor beta thalassemia is a disorder without any special symptom which only causes mild anemia. In thalassemic patients accelerated erythropoiesis and enhanced cholesterol consumption have been suggested as the dominant mechanism for low level of lipoproteins. Hyperlipidemia is a risk factor for cardiovascular diseases and hence, low level of serum lipids can act as a protective factor. Because...

In this article we report a Sardinian family, in which a beta-thalassemia gene and a triple alpha-globin loci, counterpart of the rightward deletion type alpha-thalassemia-2, were segregating. The analysis of the genotype-phenotype correlations in the different family members allowed us to give an outline of the manifestations associated with different genotype combinations. The heterozygote fo...