Elusive bugs can be particularly expensive because they often survive testing and are released in a deployed system. They are characterized as involving a combination of properties. One approach to their detection is bounded exhaustive testing (BET). This paper describes how to implement BET using a variation of JUnit, called BETUnit. The idea of a BET pattern is also introduced. BET patterns d...

This work describes methacrylic acid functionalized β-cyclodextrin (MAA-βCD) as a novel functional monomer in the preparation of molecular imprinted polymer (MIP MAA-βCD) for the selective removal of 2,4-dichlorophenol (2,4-DCP). The polymer was characterized using Fourier Transform Infrared (FTIR) spectroscopy, Brunauer-Emmett-Teller (BET) and Field Emission Scanning Electron Microscopy (FESEM...

Background Birch pollen-allergic subjects often develop Bet v 1-specific IgE that cross-reacts with homologous food allergens. Bet v 1 and its homologs in pollen and food display exclusively conformational epitopes. We established a system to specifically analyze epitope cross-reactivity of Bet v 1-related allergens. The enzyme norcoclaurine synthase (NCS) from Thalictrum flavum is structurally...

In this study, the removal of Cr(VI) from aqueous solution by modified zeolite with 3-aminopropyltriethoxysilane was investigated. The effect various parameters such as pH, contact time, temperature, initial concentration ion, common cations, and anions on adsorption studied. characterized following instrumental analysis XRD, SEM/EDS, BET, FT-IR. Based calculated thermodynamic values (ΔG0 H0 > ...

Malignant brain tumors are the most common solid tumors in children. The overall prognosis for this group of patients is still poor, emphasizing the importance of more effective therapies. Betulinic acid (Bet A) has been described as a novel cytotoxic compound active against melanoma and neuroblastoma cells. Here we report that Bet A was active against medulloblastoma and glioblastoma cell line...

The basic principles of Bounded Exhaustive Testing (BET) are reviewed, as well as the concept of an Elusive Bug (EB). Initial work on the application of BET to EB's previously indicated that it provides a new and promising approach to this problem. A four-part BET/EB oriented test framework involving: fault model development, BET test generation design, failure model identification and automate...

The transcription factor T-bet regulates the production of interferon-γ and cytotoxic molecules in effector CD8 T cells, and its expression correlates with improved control of chronic viral infections. However, the role of T-bet in infections with differential outcome remains poorly defined. Here, we report that high expression of T-bet in virus-specific CD8 T cells during acute hepatitis B vir...

Despite the recognized role of the T-bet transcription factor in the differentiation of Th1 cells, T-bet-deficient mice can develop small numbers of IFN-gamma-producing CD4 T cells. Although these are not sufficient to allow normal handling of some pathogens, T-bet-deficient mice do resolve infection with the intracellular pathogen Listeria monocytogenes. In contrast, we report that expression ...

Pancreatic ductal adenocarcinoma (PDAC) is associated with pronounced fibrosis that contributes to chemoresistance, in part, through increased histone acetylation. Because bromodomain (BRD) and extra terminal domain (BET) proteins are "readers" of histone acetylation marks, we targeted BET proteins in PDAC cells grown in three-dimensional collagen. We show that treatment with BET inhibitors dec...