Mitochondrial DNA (mtDNA) contains higher steady-state levels of oxidative damage and mutates at rates significantly greater than nuclear DNA. Oxidative lesions in mtDNA are removed by a base excision repair (BER) pathway. All mtDNA repair proteins are nuclear encoded and imported. Most mtDNA repair proteins so far discovered are either identical to nuclear DNA repair proteins or isoforms of nu...

Epidemiologic studies have revealed a complex association between human genetic variance and cancer risk. Quantitative biological modeling based on experimental data can play a critical role in interpreting the effect of genetic variation on biochemical pathways relevant to cancer development and progression. Defects in human DNA base excision repair (BER) proteins can reduce cellular tolerance...

The base excision repair (BER) process removes base damage such as oxidation, alkylation or abasic sites. Two BER sub-pathways have been characterized using in vitro methods, and have been classified according to the length of the repair patch as either 'short-patch' BER (one nucleotide) or 'long-patch' BER (LP-BER; more than one nucleotide). To investigate the occurrence of LP-BER in vivo, we ...

Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, anxiety, depression, and amnesic symptoms that may involve the release of monoamines in the fear circuit. The present study measured several anxiety-related behavioral responses to examine the effects of berberine (BER) on symptoms of anxiety in rats after s...

1. Abstract 2. Introduction 3. Materials and methods 3.1. Rat model of focal cerebral ischemia 3.2. Measurement of overall BER activity 3.3. Measurement of AP endonuclease activity 3.4. Measurement of DNA polymerase-beta activity 3.5. Western blot analysis 3.6. Quantitative measurement of AP sites in nuclear DNA 3.7. Detection of DNA single-strand breaks 3.8. Statistical analysis 4. Results 4.1...

Nucleophosmin (NPM1) is a multifunctional protein that controls cell growth and genome stability via a mechanism that involves nucleolar-cytoplasmic shuttling. It is clear that NPM1 also contributes to the DNA damage response, yet its exact function is poorly understood. We recently linked NPM1 expression to the functional activation of the major abasic endonuclease in mammalian base excision r...

Epidemiological studies have revealed a complex association between human genetic variance and cancer risk. Quantitative biological modeling based on experimental data can play a critical role in interpreting the impact of genetic variation on biochemical pathways relevant to cancer development and progression. Defects in human DNA base excision repair (BER) proteins can reduce cellular toleran...

In this paper, the bit error rate (BER) of 16 differential amplitude phase shift keying (16DAPSK) modems in future mobile communication system is derived analytically. The channel employed in this paper is the frequency-selective and fast Rayleigh fading channel, corrupted by cochannel interference (CCI) and additive white Gaussian noise (AWGN). Exact expressions for the probability distributio...

Cellulosic Ž bers have been used as cost-cutting Ž llers in plastic industry. Among the various factors, the Ž nal performance of the composite materials depends to a large extent on the adhesion between the polymer matrix and the reinforcement and therefore on the quality of the interface. To achieve optimum performance of the end product, sufŽ cient interaction between the matrix resin and th...