Phenyliodine(III) diacetate-induced oxidation of 2-(2-hydroxynaphthyl)benzoxazoles in alcohols, regioselectively afforded dearomatized products: 1-(benzoxazol-2-yl)-1-alkoxynaphthalen-2(1H)-ones and 1-(benzoxazol-2-yl)naphthalene-2,3-diones. Further, these products were also synthesized one-pot either from (E)-1-(((2-hydroxyphenyl) imino)methyl)naphthalen-2-ol or 2-aminophenol 2-hydroxynaphthal...

Sulfonic acid functionalized SBA-15 as a nanoporous acid catalyst was used in the synthesis of 2-Aryl benzoxazoles 4 by the condensation of 2-aminophenol 1 and benzoyl chlorides 2 under microwave irradiation in solvent free reaction conditions. The advantages of this methodology are good product yields (60-98%), being environmentally benign, short reaction times and easy work up.

A new series of 2,5- and/or 6-substituted benzoxazoles (7a-f), benzimidazoles (8a-g) holding cyclohexyl or cyclopentyl moieties at position 2 and 5- or 6-substituted-2-cyclohexylaminomethylbenzoxazoles (9a, b) was synthesized in order to determine their antimicrobial activities and feasible structure-activity relationships. The synthesized compounds were tested in vitro against three Gram-posit...

Detailed studies have been conducted to determine the activity of palladium catalysts for the amination of five-membered heterocyclic halides and to determine the factors that control the scope of this reaction. Palladium-catalyzed aminations of the electron-rich furanyl, thiophenyl, and indolyl halides and of the related 2-halogenated thiazoles, benzimidazole, and benzoxazole have been shown t...

Catalysts are frequently used as pelletized powdered materials, but rarely thin films. The present work reports the use of 2D h-boron nitride on few layers defective graphene (h-BN/fl-G) films about 10 nm thickness base catalyst for synthesis benzoxazoles by coupling a 2-amino-phenol with p-substituted benzaldehydes. benzoxazole derivatives has aroused much interest in last decades due to their...

The structure of 2-[(4-chlorophenylazo) cyanomethyl] benzoxazole, C15H9ClN4O (I), has triclinic ([Formula: see text]) symmetry. The structure displays N-H ⋯ N hydrogen bonding. The structure of 2-[(arylidene) cyanomethyl] benzoxazoles, C17H10N2O3 (II), has triclinic ([Formula: see text]) symmetry. The structure displays C-H ⋯ N, C-H ⋯ C hydrogen bonding. In (I), the chlorophenyl and benzoxazole...

2 The present work deals with the synthesis of some novel heterocyclic compounds such as benzoxazoles , 7, 13 and 19, imidazoles 3, 8, 14 and 20, benzimidazoles 4, 9, 15 and 21, and tetrazoles 10, 16, and 22. The synthesized compounds were characterized by IR, 1H NMR, mass spectrometry and elemental analysis. The compounds were evaluated for cytotoxicity against human cancer cell lines such as ...

In this work we carried out a study covering conformational analysis, docking calculations and molecular dynamics (MD) simulations of six excited state intramolecular proton transfer (ESIPT)-fluorescent 2-(2’-hydroxyphenyl)-benzoxazoles, interacting with the Dickerson-Drew (d(CGCGAATTCGCG)2) dodecamer in B-DNA conformation. In the analysis of the molecular docking calculations, the derivatives ...