Introduction: This work aims to develop an efficient green synthetic procedure and cytotoxicity evaluation of benzoxazole derivatives, essential building block in medicinal chemistry research owing its broad range pharmacological properties, especially anticancer activity. Methods: The microwave-assisted condensation reaction between 2-amino-4-methylphenol aromatic aldehydes using iodine as the...

Benzoxazole is one of the biologically important heterocyclic compounds, which shows remarkable pharmacological activities. In this work, 3-methyl-1-(5-methyl-1,3-benzoxazol-2-yl)-1H-pyrazol-5-amine derivatives have been synthesized by using mild protocol under solvent free condition. Structures compounds confirmed through IR, 1H NMR, 13C NMR and Mass spectral methods. All were assessed for the...

phospho sulfonic acid (psa) synthesized as an environmentally safe and efficient solid acid catalyst, and it used for the synthesis of several 2-disubstituted benzimidazoles, 2-substituted benzoxazoles, and 2-substituted quinoxalines in ethanol as a green solvent at ambient temperature is described. (i) a very simple, green and efficient procedure for the synthesis of benzimidazole and also benz...

2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to explore the less basic benzoxazole system as a replacement for the core scaffold in previously discovered benzimidazole viral translation inhibitors. Structure-activity relationships in the target binding of substituted benzoxazole ligands ...