In the mol-ecule of the title compound, C(23)H(18)BrN(3)O(3), the benzotriazole mean plane makes dihedral angles of 1.26 (1) and 87.39 (1)° with the tolyl and bromophenyl benzene rings, respectively, and the dihedral angle between the benzene rings is 87.27 (1)°. In the crystal structure, mol-ecules are linked into chains along the a axis by C-H⋯O inter-molecular hydrogen bonds. The structure i...

In the title compound, C(14)H(11)N(3)O(2), the dihedral angle between the phenyl ring and the benzotriazole ring system is 76.80 (19)° and the mol-ecule has an L-shaped conformation. In the crystal, weak aromatic π-π stacking is observed, the closest centroid-centroid distance being 3.754 (2) Å.

The first total synthesis of Rolloamide B, a cyclic proline-enriched heptapeptide, is reported. This work features solution phase benzotriazole-mediated peptide synthesis ligating native amino acids.

High-yielding syntheses of two unpublished series of amino-1,5-benzodiazepines derivatives 3 and 1,2,3-benzotriazoles 4 bearing a dimedone moiety are respectively reported. Derivatives 3 were obtained by intramolecular cyclisation using cyanogenbromide of enaminone 2. On the other hand, when enaminones 2 were treated with sodium nitrite under acidic conditions, cyclisation led to benzotriazole 4.

In the title compound, [Ni(C(12)H(9)O(2))(2)(C(7)H(6)N(2))(2)]·H(2)O, The Ni(II) cation is located on a twofold rotation axis and is six-coordinated in a distorted NiN(2)O(4) octa-hedral geometry. The asymmetric unit consists of a nickel(II) ion, one 2-(naphthalen-1-yl)acetate anion, a neutral benzotriazole ligand and one half of a lattice water mol-ecule. The crystal packing is stabilized by O...

In the title compound, C(15)H(12)ClN(5)O, the mean planes of the benzotriazole and chloro-phenyl fragments form a dihedral angle of 70.8 (1)°. In the crystal, mol-ecules are linked into infinite chains along the a axis by N-H⋯O hydrogen bonds. Weak inter-molecular C-H⋯N hydrogen bonds further link these chains into layers parallel to the ab plane. The crystal studied was a racemic twin.

In the title mol-ecule, C(24)H(19)Cl(2)N(3), the dihedral angles between the benzotriazole group and the ethyl- and dichloro-substituted benzene rings are 16.53 (1) and 82.09 (1)°, respectively. The crystal structure is stabilized by weak inter-molecular C-H⋯O inter-actions.

ABSTRACT A series of new benzimidazole and benzotriazole derivatives containing a tetrazole moiety was synthesized by N-alkylation of 5-aryltetrazole with 4,5,6,7-tetrabromo-1-(3-chloropropyl)-1H-benzimidazole and 4,5,6,7-tetrabromo-2-(3-chloropropyl)-2H-benzotriazole. The reaction was regioselective and mostly 2,5-disubstituted tetrazole derivatives were obtained. The effect of all synthesized...

Aib α-Aminoisobutyric acid or Cα-methylalanine (αMe)Phe Cα-methylphenylalanine (αMe)Val Cα-methylvaline BOP (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium CIP 2-Chloro-1,3-dimethylimidazolidium phosphate Db z g Cα,α-dibenzylglycine Deg Cα,α-diethylglycine Dφg Cα,α-diphenylglycine Dp n g Cα,α-di-n-propylglycine EDC 1-(3-Dimethylamino)propyl-3-ethylcarbodiimide HATU 2-(1H-7-aza-1,2,3-benzot...