Topical anesthetics, such as benzocaine, have been reported to cause methemoglobinemia, in which hemoglobin is unable to release oxygen effectively to body tissues. The pathophysiology, symptoms, and treatment of a 46-year-old patient are examined.

Anesthetics are often used to immobilise fishes in research. Many chemicals have been tested in anesthetisation of fishes and each chemical has its own merits and demerits. In the present study, four anesthetics namely, 2-phenoxyethanol, quinaldine, MS-222, and benzocaine were selected to test the efficiency in anesthetisation of common carp Cyprinus carpia. Results indicated that the induction...

The effects of local anaesthetics lidocaine, benzocaine, carbisocaine and carbisocaine derivatives, KaQ-7 and Ka-O, in perturbing bovine brain lipid membranes or egg lecithin membranes were compared at pH 6.0; 7.0; and 8.0. The electron spin resonance method with stearic acid labeled at carbon position 16 as the spin probe was employed. The perturbation effects of lidocaine and Ka-O were found ...

CASE REPORT An 82-year-old white woman with a history of hypertension, paroxysmal atrial tachycardia, and hypothyroidism underwent laparoscopic left adrenalectomy for possible adrenal carcinoma. On the third postoperative day, the patient’s course was complicated by a paralytic ileus. A nasogastric tube was placed, preceded by a 3-second dose of Hurricane spray (20% benzocaine, approximately 60...

The blocking effects of benzocaine and its isomers (1 mmol/l) on sodium currents in myelinated nerve fibres were tested. As far as the so-called fast sodium inactivation is concerned, benzocaine shifted the h alpha-curve in negative direction to a stronger extent than did its isomers, while the potency of the isomers did not differ significantly from each other. The drug-induced reductions of m...

It was studied in Antarctic fishes the anesthetic and/or analgesic actions of central depressors ketamine, fentanyl and thiopental as well as the local anesthetic benzocaine. The drugs were added to aerated marine water at temperatures of 1-1.5 C. Ketamine (15 mg/L) and fentanyl (50 g/L) failed in inducing anesthesia but caused a long lasting analgesia and sedation. Thiopental was required in d...

Risk assessment of sensitizing chemicals requires, besides hazard identification, the assessment of potency. To examine the sensitizing capacity of low molecular weight chemicals, a murine local lymph node assay (LLNA) was used. The sensitizing capacity of known allergens was quantified by dose-response modeling. At a stimulatory index (SI) of 3, the corresponding estimated concentration was ca...

gel dosage forms are successfully used as drug delivery systems considering their ability to control drug release and to protect medicaments from a hostile environment. the aim of this work was to investigate the properties of carbopol 934p polymeric system in water-misible cosolvents such as glycerin and alcohol. benzocaine is a local anesthetic and the mucosal gel formulation is applied in th...

A simple, accurate and sensitive method for the microdetermination of benzocaine, lignocaine and procaine hydrochlorides in pure forms and in pharmaceutical formulations is described. The procedure is based on the reaction of those drugs in an aqueous acidic medium with p-benzoquinone to form charge-transfer complexes. The method has been used for the determination of 5.0-70, 5.0-60 and 5.0-90 ...