Main results 16 RCTs met the selection criteria; 1128 patients were assigned to long bed rest and 1083 patients were assigned to immediate mobilisation or short bed rest. Cervical or lumbar puncture was used for anaesthesia (5 trials), myelography (6 trials), and diagnostic reasons (5 trials). 11 trials compared bed rest with immediate mobilisation (0.5–24 h), and 5 trials compared longer bed r...

Spaceflight and bed rest models of microgravity have profound effects on physiological systems, including the cardiovascular, musculoskeletal, and immune systems. These effects can be exacerbated by suboptimal nutrient status, and therefore it is critical to monitor nutritional status when evaluating countermeasures to mitigate negative effects of spaceflight. As part of a larger study to inves...

I n t e r v e n t i o n Patients were allocated to bed rest (n = 84), physiotherapy (n = 83), or continuation of ADLs (n = 83). Bed rest could be done at home or in the hospital and lasted 7 days. Physiotherapy sessions were scheduled twice weekly for 4 to 8 weeks and involved segmental mobilization, disc unloading and loading exercises, and hydrotherapy. Patients in the continuation-of-ADLs gr...

This study assessed the effects of inactivity on GLUT-4 content of human skeletal muscle and evaluated resistance training as a countermeasure to inactivity-related changes in GLUT-4 content in skeletal muscle. Nine young men participated in the study. For 19 days, four control subjects remained in a -6 degrees head-down tilt at all times throughout bed rest, except for showering every other da...

Deconditioning is a risk factor for cardiovascular disease. The physiology of vascular adaptation to deconditioning has not been elucidated. The purpose of the present study was to assess the effects of bed rest deconditioning on vascular dimension and function of leg conduit arteries. In addition, the effectiveness of resistive vibration exercise as a countermeasure for vascular deconditioning...

The aim was to test the hypothesis that 7 days of bed rest reduces mitochondrial number and expression and activity of oxidative proteins in human skeletal muscle but that exercise-induced intracellular signaling as well as mRNA and microRNA (miR) responses are maintained after bed rest. Twelve young, healthy male subjects completed 7 days of bed rest with vastus lateralis muscle biopsies taken...

Although spaceflight and bed rest are known to cause muscular atrophy in the antigravity muscles of the legs, the changes in sympathetic and cardiovascular responses to exercises using the atrophied muscles remain unknown. We hypothesized that bed rest would augment sympathetic responses to isometric exercise using antigravity leg muscles in humans. Ten healthy male volunteers were subjected to...

SARS-CoV-2 is a novel strain of the coronaviruses posing great challenges to the human immune system. Hence, human innate immunity determines how our body responses to the early infection (1-3). According to the studies, coronavirus can cause a range of symptoms by affecting various organs in the body (4, 5). Currently, our hospital is one of the referral centers of COVID-19 in Iran. We would l...

There are two possible mechanisms contributing to the excessive fall of stroke volume (and its contribution to orthostatic intolerance) in the upright position after bed rest or spaceflight: reduced cardiac filling due to hypovolemia and/or a less distensible heart due to cardiac atrophy. We hypothesized that preservation of cardiac mechanical function by exercise training, plus normalization o...

Adaptation to spaceflight or head-down-tilt bed rest leads to hypovolemia and an apparent abnormality of baroreflex regulation of cardiac period. In a previous study, we demonstrated that both chronic (2 wk) head-down-tilt bed rest and acute induced hypovolemia led to similar impairments in spontaneous baroreflex control of cardiac period, suggesting that a reduction in plasma volume may be res...